Results 21 to 30 of about 101,976 (254)

The role of the TrkB-T1 receptor in the neurotrophin-4/5 antagonism of brain-derived neurotrophic factor on corticostriatal synaptic transmission

Neural Regeneration Research, 2020
This manuscript reviews the function and fundamental characteristics of the neurotrophins and their receptors to introduce the reader to the differential effects exhibited by the neurotrophins; brain-derived neurotrophic factor and neurotrophin 4/5 when ...
Elizabeth Hernandez-Echeagaray
doaj   +1 more source

Phospholipase C gamma mediates endogenous brain-derived neurotrophic factor-regulated calcitonin gene-related peptide expression in colitis-induced visceral pain

Molecular Pain, 2016
Background Visceral hypersensitivity is a complex pathophysiological paradigm with unclear mechanisms. Primary afferent neuronal plasticity marked by alterations in neuroactive compounds such as calcitonin gene-related peptide is suggested to underlie ...
Fiza Hashmi MS, Miao Liu PhD, Shanwei Shen MS, Li-Ya Qiao PhD   +3 more
doaj   +1 more source

Alginate-encapsulated brain-derived neurotrophic factor–overexpressing mesenchymal stem cells are a promising drug delivery system for protection of auditory neurons

Journal of Tissue Engineering, 2020
The cochlear implant outcome is possibly improved by brain-derived neurotrophic factor treatment protecting spiral ganglion neurons. Implantation of genetically modified mesenchymal stem cells may enable the required long-term brain-derived neurotrophic ...
Jana Schwieger, Anika Hamm, Michael M. Gepp, André Schulz, Andrea Hoffmann, Thomas Lenarz, Verena Scheper   +6 more
doaj   +1 more source

S100B protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milk. [PDF]

PLoS ONE, 2011
Human milk contains a wide variety of nutrients that contribute to the fulfillment of its functions, which include the regulation of newborn development.
Ruisong Li, Wei Xia, Zhihong Zhang, Kun Wu   +3 more
doaj   +1 more source

Brain region–specific roles of brain-derived neurotrophic factor in social stress–induced depressive-like behavior

Neural Regeneration Research
Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response. Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific ...
Man Han, Deyang Zeng, Wei Tan, Xingxing Chen, Shuyuan Bai, Qiong Wu, Yushan Chen, Zhen Wei, Yufei Mei, Yan Zeng   +9 more
doaj   +1 more source

Neural stem cells over-expressing brain-derived neurotrophic factor promote neuronal survival and cytoskeletal protein expression in traumatic brain injury sites

Neural Regeneration Research, 2017
Cytoskeletal proteins are involved in neuronal survival. Brain-derived neurotrophic factor can increase expression of cytoskeletal proteins during regeneration after axonal injury.
Tao Chen, Yan Yu, Liu-jiu Tang, Li Kong, Cheng-hong Zhang, Hai-ying Chu, Liang-wei Yin, Hai-ying Ma   +7 more
doaj   +1 more source

Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders [PDF]

Pharmacological Reviews, 2012
Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases.
Anita E, Autry, Lisa M, Monteggia
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Effect of brain-derived neurotrophic factor on the formation of psycho-vegetative syndrome with brain injury [PDF]

Саратовский научно-медицинский журнал, 2016
Aim: to determine the role of brain-derived neurotrophic factor in the formation and forecasting of psycho-vegetative syndrome in patients with cerebral mild to moderate injury. Material and Methods.
Selyanina N.V., Karakulova J.V.
doaj