Results 41 to 50 of about 236,444 (370)

Long-term neuroprotection and neurorestoration by glial cell-derived neurotrophic factor microspheres for the treatment of parkinson's disease [PDF]

, 2011
BACKGROUND: Glial cell-derived neurotrophic factor is a survival factor for dopaminergic neurons and a promising candidate for the treatment of Parkinson's disease. However, the delivery issue of the protein to the brain still remains unsolved.
Ansorena-Artieda, E. (Eduardo), Aymerich-Soler, M. S. (María S.), Blanco-Prieto, M.J. (María José), Garbayo, E, Lanciego, J.L. (José Luis)   +4 more
core   +1 more source

Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities

Journal of Neural Transplantation and Plasticity, 2020
With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society. Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute
Wei Liu, Xiaohui Wang, M. O'Connor, Guan Wang, Fang Han   +4 more
semanticscholar   +1 more source

Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]

, 1993
Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., Markus, A., Wittinghofer, A.   +4 more
core   +3 more sources

Determinants of serum brain-derived neurotrophic factor

Psychoneuroendocrinology, 2011
Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of growth factors and affects the survival and plasticity of neurons in the adult central nervous system. The high correlation between cortical and serum BDNF levels has led to many human studies on BDNF levels in various populations, however knowledge about determinants that ...
Jos Prickaerts, Boudewijn A.A. Bus, B.J.W.H. Penninx, B.J.W.H. Penninx, B.J.W.H. Penninx, R.C. Oude Voshaar, Marc L. Molendijk, Jan K. Buitelaar, Bernet M. Elzinga, Gunter Kenis   +9 more
openaire   +7 more sources

Brain-derived neurotrophic factor and cocaine addiction [PDF]

Brain Research, 2010
The effects of brain-derived neurotrophic factor (BDNF) on cocaine-seeking are brain region-specific. Infusion of BDNF into subcortical structures, like the nucleus accumbens and ventral tegmental area, enhances cocaine-induced behavioral sensitization and cocaine-seeking. Conversely, repeated administration of BDNF antiserum into the nucleus accumbens
William J. Berglind, Timothy W. Whitfield, Jacqueline F. McGinty   +2 more
openaire   +3 more sources

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

Molecular Neurobiology, 2020
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that plays a crucial role in the development of the nervous system while supporting the survival of existing neurons and instigating neurogenesis.
C. Eyileten, Lucia Sharif, Z. Wicik, D. Jakubik, J. Jarosz-Popek, A. Soplinska, M. Postuła, A. Członkowska, A. Kapłon-Cieślicka, D. Mirowska-Guzel   +9 more
semanticscholar   +1 more source

Leukemia Inhibitory Factor Augments Neurotrophin Expression and Corticospinal Axon Growth after Adult CNS Injury [PDF]

, 1999
The cytokine leukemia inhibitory factor (LIF) modulates glial and neuronal function in development and after peripheral nerve injury, but little is known regarding its role in the injured adult CNS.
Blesch, A., Cheng, J.-G., Grill, R. J., Patterson, P. H., Tuszynski, M. H., Uy, H. S.   +5 more
core   +1 more source

The role of the TrkB-T1 receptor in the neurotrophin-4/5 antagonism of brain-derived neurotrophic factor on corticostriatal synaptic transmission

Neural Regeneration Research, 2020
This manuscript reviews the function and fundamental characteristics of the neurotrophins and their receptors to introduce the reader to the differential effects exhibited by the neurotrophins; brain-derived neurotrophic factor and neurotrophin 4/5 when ...
Elizabeth Hernandez-Echeagaray
doaj   +1 more source

Brain-derived neurotrophic factor and its clinical implications

Archives of medical science : AMS, 2015
Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory.
Siresha Bathina, U. Das
semanticscholar   +1 more source

Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence [PDF]

, 2011
Depression is a neuropsychiatric disorder affecting a huge percentage of the active population especially in developed countries. Research has devoted much of its attention to this problematic and many drugs have been developed and are currently ...
Berrocoso Domínguez, Esther María, Borges, Gisela, Micó Segura, Juan Antonio, Neto, Fani L., Torres-Sanchez, Sonia   +4 more
core   +4 more sources