TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death [PDF]
, 1997 Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant
Alcántara Horrillo, Soledad +5 more
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Neural Regeneration Research, 2015 Treatment for optic nerve injury by brain-derived neurotrophic factor or the transplantation of human umbilical cord blood stem cells has gained progress, but analysis by biomechanical indicators is rare.
Zhong-jun Zhang +7 more
doaj +1 more source
International Journal of Molecular Sciences, 2019 Findings from previous studies reporting the levels of serum brain-derived neurotrophic factor (BDNF) in patients with Alzheimer’s disease (AD) and individuals with mild cognitive impairment (MCI) have been conflicting.
T. Ng, C. Ho, W. Tam, E. Kua, R. Ho
semanticscholar +1 more source
Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]
, 2018 Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R +8 more
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Promoting neurogenesis in hippocampal dentate gyrus of chronic unpredictable stress-induced depressive-like rats with paeoniflorin [PDF]
Journal of Integrative Neuroscience, 2019 Hippocampal neurogenesis plays an important role in the onset and treatment of depressive disorders. Previous studies suggest that paeoniflorin could be used as an antidepressant for treating rats subjected to chronic unpredictable stress. In this study,
Li-Bing Chen, Feng-Mei Qiu, Xiao-Ming Zhong, Cheng Hong, Zhen Huang
doaj +1 more source
Safety and feasibility of Lin- cells administration to ALS patients : a novel view on humoral factors and miRNA profiles [PDF]
, 2018 Therapeutic options for amyotrophic lateral sclerosis (ALS) are still limited. Great hopes, however, are placed in growth factors that show neuroprotective abilities (e.g., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular
Baumert, Bartłomiej +12 more
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Effect of brain-derived neurotrophic factor on the formation of psycho-vegetative syndrome with brain injury [PDF]
Саратовский научно-медицинский журнал, 2016 Aim: to determine the role of brain-derived neurotrophic factor in the formation and forecasting of psycho-vegetative syndrome in patients with cerebral mild to moderate injury. Material and Methods.
Selyanina N.V., Karakulova J.V.
doaj
Brain-derived neurotrophic factor associated with kidney function
Diabetology & Metabolic Syndrome, 2023 Background We examined the relationship between brain-derived neurotrophic factor (BDNF) and chronic kidney disease (CKD). Methods First, a cross-sectional study was conducted in 480 participants without known diabetes.
Cheng-Yueh Hsu +2 more
doaj +1 more source
Drosophila Neurotrophins Reveal a Common Mechanism for Nervous System Formation [PDF]
, 2008 Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been found. Neurotrophins are the main vertebrate secreted signalling molecules that link nervous system structure and function: they regulate neuronal survival ...
Aberle +136 more
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Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically defined cohort of patients.
Patrizia Pignataro +12 more
wiley +1 more source