Results 261 to 270 of about 2,520,525 (306)
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Science Signaling, 2022
An advanced glycation end product (AGE) links the gut microbiome, a “leaky gut,” and microglial aging.
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An advanced glycation end product (AGE) links the gut microbiome, a “leaky gut,” and microglial aging.
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Annual Review of Pathology: Mechanisms of Disease, 2006
Aging is accompanied by cognitive decline in a major segment of the population and is the primary risk factor for Alzheimer's disease and other prevalent neurodegenerative disorders. Despite this central role in disease pathogenesis and morbidity, the aging of the brain has not been well understood at a molecular level.
Bruce A, Yankner +2 more
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Aging is accompanied by cognitive decline in a major segment of the population and is the primary risk factor for Alzheimer's disease and other prevalent neurodegenerative disorders. Despite this central role in disease pathogenesis and morbidity, the aging of the brain has not been well understood at a molecular level.
Bruce A, Yankner +2 more
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Mechanisms of Ageing and Development, 2002
The brains of individuals who are cognitively normal show age-related changes that include an overall reduction in the brain volume and weight and enlargement of the brain ventricles. These changes are partly the result of nerve cell loss but accurate estimates of neuronal loss are notoriously difficult to make.
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The brains of individuals who are cognitively normal show age-related changes that include an overall reduction in the brain volume and weight and enlargement of the brain ventricles. These changes are partly the result of nerve cell loss but accurate estimates of neuronal loss are notoriously difficult to make.
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Experimental Gerontology, 1971
Abstract The activities of various enzymes involved in amine turnover were studied as a function of age (2–29 months) in rat caudate and whole brain minus caudate and cerebellum. The only significant changes with age (decreases) found were in tyrosine hydroxylase, choline acetylase and glutamic decarboxylase in the caudate nucleus. The sharp decrease
E G, McGeer +3 more
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Abstract The activities of various enzymes involved in amine turnover were studied as a function of age (2–29 months) in rat caudate and whole brain minus caudate and cerebellum. The only significant changes with age (decreases) found were in tyrosine hydroxylase, choline acetylase and glutamic decarboxylase in the caudate nucleus. The sharp decrease
E G, McGeer +3 more
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Ageing Research Reviews, 2002
The proteasome is a large intracellular protease, present in all cells of the central nervous system (CNS), that is responsible for the majority of intracellular protein degradation. In particular, the proteasome is responsible for the degradation of most oxidized, aggregated, and misfolded proteins.
Jeffrey N, Keller +2 more
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The proteasome is a large intracellular protease, present in all cells of the central nervous system (CNS), that is responsible for the majority of intracellular protein degradation. In particular, the proteasome is responsible for the degradation of most oxidized, aggregated, and misfolded proteins.
Jeffrey N, Keller +2 more
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Acta Neurologica Scandinavica, 1992
A recent interest in aging of the nervous system is related to the remarkable increase in the numbers of elderly persons throughout the world. As a reflection of the added years, pathologies in the older person have also increased. Primary among those which affect the activities and behavior of these people are the dementias, especially Alzheimer's ...
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A recent interest in aging of the nervous system is related to the remarkable increase in the numbers of elderly persons throughout the world. As a reflection of the added years, pathologies in the older person have also increased. Primary among those which affect the activities and behavior of these people are the dementias, especially Alzheimer's ...
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Clinics in Geriatric Medicine, 1985
Changes in neurons, glial cells, synapse morphologic and electrophysiologic appearance, and neurotransmission mechanisms during normal aging are considered for review in this article. These processes not only are fundamental in the neurobiology of normal aging but also are implicated in the pathogenesis of aging.
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Changes in neurons, glial cells, synapse morphologic and electrophysiologic appearance, and neurotransmission mechanisms during normal aging are considered for review in this article. These processes not only are fundamental in the neurobiology of normal aging but also are implicated in the pathogenesis of aging.
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Lipopigment in the aging brain
American Journal of Medical Genetics, 1988Accumulation of lipopigments in neurons, glial, and other cells is the most characteristic change associated with the aging brain. Lipopigments are bipartite granules consisting of an autofluorescent electron-dense pigment and electron-lucent lipid components. Both components are enclosed by a common, continuous unit membrane.
H. M. Wisniewski +4 more
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Annals of Neurology, 1985
AbstractPostmortem and computed tomographic studies demonstrate many anatomical, morphological, and neurochemical differences between brains of old and young human beings. The variability of the results is great, however, and brains of some old subjects have characteristics of brains of younger controls.
H, Creasey, S I, Rapoport
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AbstractPostmortem and computed tomographic studies demonstrate many anatomical, morphological, and neurochemical differences between brains of old and young human beings. The variability of the results is great, however, and brains of some old subjects have characteristics of brains of younger controls.
H, Creasey, S I, Rapoport
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The aging brain and anesthesia
Current Opinion in Anaesthesiology, 2013To review the neurophysiology and neuroanatomy of normal aging and the recent recommendations for the clinical management of general anesthesia and sedation in the elderly.As the population ages, the number of elderly patients having surgery is likewise increasing and with it, the prevalence of postoperative cognitive disorders. Postoperative cognitive
Emery N, Brown, Patrick L, Purdon
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