Results 191 to 200 of about 3,213,606 (302)

1,2‐propanediol reformulation improves tribromoethanol safety and reveals pontine GABRA1 enrichment as a candidate mechanistic correlate of anesthesia

Animal Models and Experimental Medicine, EarlyView.
This study develops a reformulated tribromoethanol (TBE) anesthetic using 1,2‐propanediol as a solvent to overcome solvent‐related toxicity. The novel formulation demonstrates, cardiovascular stability, and survival in prolonged protocols. It provides potent, dose‐dependent anesthesia without strain or sex differences.
Xia Li, Yanming Chen, Xinyi Xiao, Guoheng Xu   +3 more
wiley   +1 more source

Genetic Resilience and Resistance in Alzheimer's Disease Diagnosis and Pathology

Annals of Neurology, EarlyView.
Objective Some individuals avoid Alzheimer's disease (AD) pathology as they age, or retain cognition despite substantial pathology, suggesting mechanisms of resistance or resilience to neurodegeneration. Educational attainment (EA) is associated with reduced risk of cognitive decline, although the underlying mechanisms remain unclear.
Ganna Leonenko, Kalliopi Mavromati, Lynne Hughes, Jonas S. Sundarakumar, Keeley Brookes, Kevin Morgan, Terry Quinn, Valentina Escott‐Price, the Alzheimer's Disease Neuroimaging Initiative   +8 more
wiley   +1 more source

Fluid preservation in brain banking: a review.

Free neuropathology
Fluid preservation is nearly universally used in brain banking to store fixed tissue specimens for future research applications. However, the effects of long-term immersion on neural circuitry and biomolecules are not well characterized. As a result, there is a need to synthesize studies investigating fluid preservation of brain tissue.
Andrew McKenzie, Oge Nnadi, Kat D. Slagell, Emma L. Thorn, Kurt Farrell, John F. Crary   +5 more
openaire   +2 more sources

Early subtypes and progressions of progressive supranuclear palsy: a data-driven brain bank study. [PDF]

J Neurol
Ono D, Sekiya H, Ghayal NB, Maier AR, Roemer SF, Uitti RJ, Litvan I, Josephs KA, Wszolek ZK, Dickson DW.   +9 more
europepmc   +1 more source

Increased Incidence of Epilepsy in a Brain Bank Alzheimer's Disease Cohort and Its Association With TDP-43 Pathology. [PDF]

Neuropathol Appl Neurobiol
Rocca F, Kennedy J, Osman S, Reisz Z, King A, Bodi I, Al-Sarraj S, Troakes C.   +7 more
europepmc   +1 more source

Redescription of the cranial morphology of Amphisbaena braestrupi and Amphisbaena laurenti (Squamata: Amphisbaenidae) from the Pleistocene of Brazil using x‐ray computed tomography

The Anatomical Record, EarlyView.
Abstract Amphisbaenians (Squamata: Amphisbaenidae) are fossorial reptiles with highly specialized cranial morphology, yet their fossil record is frequently limited by fragmentary preservation. This study provides a detailed osteological redescription of the skulls of Amphisbaena braestrupi and Amphisbaena laurenti from the Pleistocene of Lagoa Santa ...
Carolina L. Paiva, Henrique C. Costa, Christy A. Hipsley   +2 more
wiley   +1 more source

Body donor programs in Australia and New Zealand: Current status and future opportunities

Anatomical Sciences Education, Volume 18, Issue 3, Page 301-328, March 2025.
Abstract Body donation is critical to anatomy study in Australia and New Zealand. Annually, more than 10,000 students, anatomists, researchers, and clinicians access tissue donated by local consented donors through university‐based body donation programs. However, little research has been published about their operations.
Rebekah A. Jenkin, Kevin A. Keay
wiley   +1 more source

Evaluating discrepancies between high‐yield neuroscience conditions in preclerkship medical education and national clinical incidence

Anatomical Sciences Education, EarlyView.
Abstract Medical education must balance foundational science with clinical relevance. Increasing emphasis on standardized assessments has led to prioritization of “high‐yield” conditions—those most likely to be assessed. Subsequently, educators and students often prioritize these conditions.
Kathryn Veazey, Oheneba Boadum
wiley   +1 more source

Validating the Accuracy of Parkinson's Disease Clinical Diagnosis: A UK Brain Bank Case-Control Study. [PDF]

Ann Neurol
di Biase L, Pecoraro PM, Di Lazzaro V.
europepmc   +1 more source

Exploring 3D anatomy: A free online course supporting novice learner inquiry and spatial conceptualization

Anatomical Sciences Education, EarlyView.
Abstract Application of three‐dimensional anatomical knowledge is essential for patient examination, diagnosis, and treatment and is crucial in the training of medical and healthcare students. Moreover, critical observation and spatial awareness are vital for learner understanding of three‐dimensional anatomical structures and relationships.
Jiayi Zhang, Moksh Sachdeva, Calum McCaig, Eleanor Gordon, Leonard Shapiro, Iain D. Keenan   +5 more
wiley   +1 more source