Results 21 to 30 of about 3,213,606 (302)
European Journal of Psychotraumatology, 2017 The personal, social and economic burden of post-traumatic stress disorder (PTSD) is high and therapeutic approaches are only partially effective. Therefore, there is an urgent need to understand the cellular and molecular alterations in PTSD brains in ...
Geertje M. de Lange
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Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s
Acta Neuropathologica Communications, 2022 Background The molecular drivers of early sporadic Parkinson’s disease (PD) remain unclear, and the presence of widespread end stage pathology in late disease masks the distinction between primary or causal disease-specific events and late secondary ...
Christina E. Toomey +19 more
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Brain Pathology, 2007 One avenue of progress toward understanding the neurobiological basis of autism is through the detailed study of the post‐mortem brain from affected individuals. The primary purpose of autism brain tissue banking is to make well‐characterized and optimally preserved post‐mortem brain tissue available to the neuroscience research community.
Vahram, Haroutunian, Jane, Pickett
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Fluids and Barriers of the CNS, 2022 Background Cerebral amyloid angiopathy (CAA) occurs in 80% of patients with Alzheimer’s disease (AD) and is mainly caused by the abnormal deposition of Aβ in the walls of cerebral blood vessels.
Takumi Handa +4 more
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Reduced levels of Aβ 40 and Aβ 42 in brains of smoking controls and Alzheimer's patients
Neurobiology of Disease, 2004 The effects of nicotine on levels of Aβ 40 and Aβ 42 and nicotinic receptor binding sites were studied in brains from nonsmoking and smoking patients with Alzheimer's disease (AD) and aged-matched controls.
E Hellström-Lindahl +3 more
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npj Parkinson's Disease, 2023 The abnormal aggregation and accumulation of alpha-synuclein (aSyn) in the brain is a defining hallmark of synucleinopathies. Various aSyn conformations and post-translationally modified forms accumulate in pathological inclusions and vary in abundance ...
Melek Firat Altay +8 more
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Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2018 With the financial assistance from two donors, we have established a neurodegenerative disease brain bank at the University of Calgary. At autopsy, tissues from anatomically specific regions are frozen in liquid nitrogen vapour and stored in small, bar-coded cryovials.
J.T. Joseph +4 more
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Microglial burden, activation and dystrophy patterns in frontotemporal lobar degeneration
Journal of Neuroinflammation, 2020 Background Microglial dysfunction is implicated in frontotemporal lobar degeneration (FTLD). Although studies have reported excessive microglial activation or senescence (dystrophy) in Alzheimer’s disease (AD), few have explored this in FTLD. We examined
Ione O. C. Woollacott +6 more
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Inter-American Development Bank Quarterly Business Review: First Quarter 2019
, 2019 The 2019 first quarter edition of the Quarterly Business Review (QBR) provides management with a status of the Bank\u27s performance. The QBR reports on outputs, lending program priorities and organizational indicators on a quarterly basis to allow ...
Inter-American Development Bank
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Ceylon Medical Journal, 2009 Our ageing population has a high prevalence of neurodegenerative diseases, and infectious diseases of the nervous system are emerging in Asia. Extrapolation from animal research to humans has the disadvantage of species differences in anatomy, physiology, biochemistry, and genetics.
K R D, De Silva +3 more
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