Results 51 to 60 of about 338,090 (265)
Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs
iScienceSummary: Cancer prevention is a serious global challenge. We aimed to investigate the relationship between lipid-lowering drugs and cancers. We included participants based on the UK Biobank.
Zinuo Yuan +9 more
doaj +1 more source
Nicotinamide Improves Cognitive Function in Mice With Chronic Cerebral Hypoperfusion
Frontiers in Neurology, 2021 Normal brain function requires steady blood supply to maintain stable energy state. When blood supply to the brain becomes suboptimal for a long period of time, chronic cerebral hypoperfusion (CCH) and a variety of brain changes may occur.
Bin Liu +3 more
doaj +1 more source
Brain sterol metabolism : modulating Alzheimer’s disease [PDF]
, 2021 This dissertation shows that stimulating the processing of cholesterol (turnover) in the brains of Alzheimer mice (by means of medication) can turn around the cognitive regression that characterizes the disease. It was also shown that the natural stimulation of the cholesterol turnover with plantsterols leads to an irreversible accumulation of these ...
openaire +2 more sources
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Frontiers in EndocrinologyObjectiveThe exact relationship between the serum uric acid-to-HDL cholesterol ratio (UHR) and mortality rates remains enigmatic among American adults. This study aims to clarify the association between UHR and both all-cause and cardiovascular disease ...
Zhanbin Li +12 more
doaj +1 more source
Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS
Frontiers in Nutrition, 2018 Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear.
Lijing Xin +8 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
TGR5 signalling in heart and brain injuries: focus on metabolic and ischaemic mechanisms
Neurobiology of DiseaseThe heart and brain are the core organs of the circulation and central nervous system, respectively, and play an important role in maintaining normal physiological functions. Early neuronal and cardiac damage affects organ function.
Nan Xu +9 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Brain–gut–adipose-tissue communication pathways at a glance
Disease Models & Mechanisms, 2012 One of the ‘side effects’ of our modern lifestyle is a range of metabolic diseases: the incidence of obesity, type 2 diabetes and associated cardiovascular diseases has grown to pandemic proportions. This increase, which shows no sign of reversing course,
Chun-Xia Yi, Matthias H. Tschöp
doaj +1 more source