Results 61 to 70 of about 2,001,224 (334)

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]

, 2017
There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas, Fedrowitz, Maren, Hampel, Philip, Kaczmarek, Edith, Löscher, Wolfgang, Römermann, Kerstin, Sweet, Douglas H., Töllner, Kathrin   +7 more
core   +2 more sources

Multiple Sclerosis and Seizure Prevalence

Pediatric Neurology Briefs, 2014
Investigators from Oslo University Hospital and other centers in Norway studied changes in the prevalence and incidence of multiple sclerosis (MS) in Vestfold County, Norway, in the period 1983-2003.
J Gordon Millichap, John J Millichap
doaj   +1 more source

γδ T Cells in Brain Homeostasis and Diseases

Frontiers in Immunology, 2022
γδ T cells are a distinct subset of T cells expressing γδ T cell receptor (TCR) rather than αβTCR. Since their discovery, the critical roles of γδ T cells in multiple physiological systems and diseases have been investigated.
Jang Hyun Park, In Kang, Heung Kyu Lee
doaj   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

A retrospective study of quadrigeminal arachnoid cysts diagnosed by Magnetic Resonance Imaging and Computed Tomography in 26 dogs

Pesquisa Veterinária Brasileira
: Arachnoid cysts are accumulations of cerebrospinal fluid that occur within the arachnoid membrane due to the splitting or duplication of this structure.
Lidiane S. Alves, Diego Rodriguez, Vânia M.V. Machado, Maria J. Mamprim, Luiz C. Vulcano, Rogério M. Amorim   +5 more
doaj   +1 more source

The Phytochemical Potential for Brain Disease Therapy and the Possible Nanodelivery Solutions for Brain Access

Frontiers in Oncology, 2022
Plant-derived phytochemicals have gifted humans with vast therapeutic potentials. Yet, the unique features of the blood–brain barrier significantly limit their accession to the target tissue and thus clinical translation in brain disease treatment ...
Yang Liu, Yang Liu, Zhouchun Chen, Zhouchun Chen, Aijie Li, Aijie Li, Runhan Liu, Runhan Liu, Haoying Yang, Haoying Yang, Xue Xia, Xue Xia   +11 more
doaj   +1 more source

Cavitation Feedback Control of Focused Ultrasound Blood-Brain Barrier Opening for Drug Delivery in Patients with Parkinson’s Disease [PDF]

, 2022
Yuexi Huang, Ying Meng, Christopher B. Pople, Allison Bethune, Ryan M. Jones, Agessandro Abrahão, Clement Hamani, Suneil K. Kalia, Lorraine V. Kalia, Nir Lipsman, Kullervo Hynynen   +10 more
openalex   +1 more source

Patient‐Level Barriers and Facilitators to Inpatient Physical Therapy in Adolescents and Young Adults With a Hematological Malignancy: A Qualitative Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite their increased risk for functional impairment resulting from cancer and its treatments, few adolescents and young adults (AYAs) with a hematological malignancy receive the recommended or therapeutic dose of exercise per week during inpatient hospitalizations.
Jennifer A. Kelleher, Jennifer L. Bernstein, Katia M. Crisler, Julia K. Herriott, Kimberly L. Klages, Robin E. Norris, Mariann L. Strenk, Sarah E. Bills, Meghan E. McGrady   +8 more
wiley   +1 more source

Continuous Dictionary of Nodes Model and Bilinear-Diffusion Representation Learning for Brain Disease Analysis

Brain Sciences
Brain networks based on functional magnetic resonance imaging (fMRI) provide a crucial perspective for diagnosing brain diseases. Representation learning has recently attracted tremendous attention due to its strong representation capability, which can ...
Jiarui Liang, Tianyi Yan, Yin Huang, Ting Li, Songhui Rao, Hongye Yang, Jiayu Lu, Yan Niu, Dandan Li, Jie Xiang, Bin Wang   +10 more
doaj   +1 more source

Cerebral cholesterol granuloma: case report Granuloma de colesterol cerebral: relato de caso

Arquivos de Neuro-Psiquiatria, 2007
Intracranial cholesterol granulomas are rare lesions, and have been registered in petrous apex region. The presence of an intracerebral cholesterol granuloma is an uncommun event.
Rodrigo Mendonça, Cleiton Schweitzer Peron, Marco Antônio Stefani, Pasquale Gallo   +3 more
doaj   +1 more source