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Animal models have played a critical role in elucidating the complex pathogenesis of traumatic brain injury, the major cause of death and disability in young adults in Western countries. This review discusses how different types of animal models are useful for the study of neuropathologic processes in traumatic, blunt, nonmissile head injury.
Finnie, J., Blumbergs, P.
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There is an increasing incidence of military traumatic brain injury (TBI), and similar injuries are seen in civilians in war zones or terrorist incidents. Indeed, blast-induced mild TBI has been referred to as the signature injury of the conflicts in Iraq and Afghanistan.
Jane E, Risdall, David K, Menon
openaire +4 more sources
Mild traumatic brain injury (mTBI), commonly known as concussion, is one of the most common neurologic disorders [1]. Based on emergency room visits, hospitalizations, and deaths, an estimated 1.7 million people sustain a traumatic brain injury (TBI) annually in the United States [2]. About 80% of TBIs that occur each year are mild TBI [3].
Greenwald, Brian D. +2 more
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Objective To analyze the influencing factors for tracheostomy decannulation in patients with prolonged disorders of consciousness. Methods Clinical data of 59 cases with prolonged disorders of consciousness and having undergone tracheotomy in Guangdong ...
HE Yanbin +4 more
doaj +1 more source
Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. [PDF]
The complexity of the traumatic brain injury (TBI) pathology, particularly concussive injury, is a serious obstacle for diagnosis, treatment, and long-term prognosis. Here we utilize modern systems biology in a rodent model of concussive injury to gain a
Agrawal, Rahul +5 more
core +2 more sources
We recently reported that the neuropathic pain medication, gabapentin (GBP; Neurontin), significantly attenuated both noxious colorectal distension (CRD)-induced autonomic dysreflexia (AD) and tail pinch-induced spasticity compared to saline-treated ...
Alexander G. Rabchevsky +12 more
doaj +1 more source
Genetic Approach to Elucidate the Role of Cyclophilin D in Traumatic Brain Injury Pathology
Cyclophilin D (CypD) has been shown to play a critical role in mitochondrial permeability transition pore (mPTP) opening and the subsequent cell death cascade.
Ryan D. Readnower +4 more
doaj +1 more source
Neurological consequences of traumatic brain injuries in sports. [PDF]
Traumatic brain injury (TBI) is common in boxing and other contact sports. The long term irreversible and progressive aftermath of TBI in boxers depicted as punch drunk syndrome was described almost a century ago and is now widely referred as chronic ...
Hardy, J, Ling, H, Zetterberg, H
core +1 more source
Traumatic brain injuries [PDF]
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe. Mild TBI (the least severe form) is synonymous with concussion and is typically caused by blunt non-penetrating head trauma. The trauma causes stretching and tearing of axons, which leads to diffuse axonal injury - the best-studied pathogenetic mechanism of ...
Blennow, K +7 more
openaire +7 more sources
Prevention Strategies of Traumatic Brain Injury in Football Players [PDF]
In this project, we study the effects of the impact angle during a helmet-to-helmet collision on stress distribution and deacceleration values of the brain tissue in efforts to reduce brain injuries for football players.
Baxter, Gary +3 more
core +1 more source

