Diffuse axonal injury predicts neurodegeneration after moderate-severe traumatic brain injury.
Brain : a journal of neurology, 2020 Traumatic brain injury is associated with elevated rates of neurodegenerative diseases such as Alzheimer's disease and chronic traumatic encephalopathy. In experimental models, diffuse axonal injury triggers post-traumatic neurodegeneration, with axonal ...
Neil S N Graham +7 more
semanticscholar +1 more source
Sports-related brain injury in the general population: An epidemiological study [PDF]
, 2014 Objectives To determine the incidence, nature and severity of all sports-related brain injuries in the general population. Design Population-based epidemiological incidence study.
Dowell, Tony +6 more
core +2 more sources
Frontiers in Physiology, 2012 We recently reported that the neuropathic pain medication, gabapentin (GBP; Neurontin), significantly attenuated both noxious colorectal distension (CRD)-induced autonomic dysreflexia (AD) and tail pinch-induced spasticity compared to saline-treated ...
Alexander G. Rabchevsky +12 more
doaj +1 more source
Genetic Approach to Elucidate the Role of Cyclophilin D in Traumatic Brain Injury Pathology
Cells, 2021 Cyclophilin D (CypD) has been shown to play a critical role in mitochondrial permeability transition pore (mPTP) opening and the subsequent cell death cascade.
Ryan D. Readnower +4 more
doaj +1 more source
Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I [PDF]
, 2007 Glutaric acidemia type I (GA-I) is an inherited disorder of lysine and tryptophan metabolism presenting with striatal lesions anatomically and symptomatically similar to Huntington disease.
Banos +30 more
core +3 more sources
Mechanisms of Blood–Brain Barrier Dysfunction in Traumatic Brain Injury
International Journal of Molecular Sciences, 2020 Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United States with roughly two million TBIs occurring annually. Due to the spectrum of severity and heterogeneity in TBIs, investigation into the secondary injury is
Alison M. Cash, M. Theus
semanticscholar +1 more source
Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation. [PDF]
, 2017 Brain injury elicits a systemic acute-phase response (APR), which is responsible for co-ordinating the peripheral immunological response to injury.
B Moser +46 more
core +3 more sources
Evidence of the role of the cerebellum in cognitive theory of mind using voxel-based lesion mapping
Scientific Reports, 2022 Theory of Mind (ToM) is a social-cognitive skill that allows the understanding of the intentions, beliefs, and desires of others. There is a distinction between affective and cognitive ToM, with evidence showing that these processes rely on partially ...
Pierre-Aurélien Beuriat +5 more
doaj +1 more source
Data-driven decomposition of brain dynamics with principal component analysis in different types of head impacts [PDF]
, 2021 Strain and strain rate are effective traumatic brain injury predictors. Kinematics-based models estimating these metrics suffer from significant different distributions of both kinematics and the injury metrics across head impact types. To address this, previous studies focus on the kinematics but not the injury metrics.
arxiv +1 more source
Disconnection of network hubs and cognitive impairment after traumatic brain injury. [PDF]
, 2015 Traumatic brain injury affects brain connectivity by producing traumatic axonal injury. This disrupts the function of large-scale networks that support cognition.
Fagerholm, ED +4 more
core +1 more source