Results 41 to 50 of about 2,811,049 (348)

Study of protein expresion [sic] in peri-infarct tissue after cerebral ischemia [PDF]

, 2015
In this work, we report our study of protein expression in rat peri-infarct tissue, 48 h after the induction of permanent focal cerebral ischemia. Two proteomic approaches, gel electrophoresis with mass spectrometry and combined fractional diagonal ...
Agulla, Jesús, Blanco, Miguel, Brea, David, Campos, Francisco, Castillo, José, Dávalos, Antoni, Gevaert, Kris, Ramos-Cabrer, Pedro, Sobrino, Tomás, Staes, An   +9 more
core   +5 more sources

Role of mTORC1 Controlling Proteostasis after Brain Ischemia

Frontiers in Neuroscience, 2018
Intense efforts are being undertaken to understand the pathophysiological mechanisms triggered after brain ischemia and to develop effective pharmacological treatments.
M. Pérez‐Álvarez, Mario Villa González, Irene Benito-Cuesta, F. Wandosell   +3 more
semanticscholar   +1 more source

Autophagy-mediated occludin degradation contributes to blood–brain barrier disruption during ischemia in bEnd.3 brain endothelial cells and rat ischemic stroke models

Fluids and Barriers of the CNS, 2020
The blood–brain barrier (BBB) maintains homeostasis of the brain environment by tightly regulating the entry of substances from systemic circulation.
Kyeong-A Kim, Donghyun Kim, Jeong-Hyeon Kim, Young-Jun Shin, Eun-Sun Kim, M. Akram, Eun-Hye Kim, A. Majid, Seung-Hoon Baek, O. Bae   +9 more
semanticscholar   +1 more source

Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia

Neurobiology of Disease, 2012
Evidence suggests an association between brain ischemia and Alzheimer's disease (AD) development. Amyloid plaques consisted of β-amyloid peptide (Aβ) in the brain are a pathological hallmark of AD. Little is known about how brain ischemia induces AD-like
Jiejie Li, Wenli Sheng, Chenzhuo Feng, Zhiyi Zuo   +3 more
doaj   +1 more source

Protective Action of Indapamide, a Thiazide-Like Diuretic, on Ischemia-Induced Injury and Barrier Dysfunction in Mouse Brain Microvascular Endothelial Cells

Journal of Pharmacological Sciences, 2007
The aim of the present study was to elucidate the effects of indapamide on ischemic damage to the blood-brain barrier (BBB) in vitro. The ischemia /reperfusion conditions employed here significantly decreased the viability of mouse brain capillary ...
Tsuyoshi Nishioku, Fuyuko Takata, Atsushi Yamauchi, Noriko Sumi, Ikumi Yamamoto, Akiko Fujino, Mikihiko Naito, Takashi Tsuruo, Hideki Shuto, Yasufumi Kataoka   +9 more
doaj   +1 more source

Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer’s Disease Phenotype

International Journal of Molecular Sciences, 2018
In recent years, ongoing interest in ischemic brain injury research has provided data showing that ischemic episodes are involved in the development of Alzheimer’s disease-like neuropathology.
R. Pluta, Marzena Ułamek-Kozioł, S. Czuczwar   +2 more
semanticscholar   +1 more source

The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus

Neural Regeneration Research, 2017
Myocardial ischemia/reperfusion injury can lead to severe brain injury. Glycogen synthase kinase 3 beta is known to be involved in myo-cardial ischemia/reperfusion injury and diabetes mellitus. However, the precise role of glycogen synthase kinase 3 beta
Bo Zhao, Wen-wei Gao, Ya-jing Liu, Meng Jiang, Lian Liu, Quan Yuan, Jia-bao Hou, Zhong-yuan Xia   +7 more
doaj   +1 more source

Cofilin-actin rod formation in neuronal processes after brain ischemia

bioRxiv, 2018
Functional impairment after brain ischemia results in part from loss of neuronal spines and dendrites, independent of neuronal death. Cofilin-actin rods are covalently linked aggregates of colfilin-1 and actin that form in neuronal processes (neurites ...
S. Won, Angela M. Minnella, Long Wu, Claire H Eun, E. Rome, A. Shaw, P. Herson, J. Bamburg, R. Swanson   +8 more
semanticscholar   +1 more source

Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells

Journal of Neuroinflammation, 2023
Background and purpose Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-related deaths worldwide. Current treatments are limited, and new, more effective prevention and treatment strategies
Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu, Yanni Lv   +7 more
doaj   +1 more source

Cognitive function restoration in rats with chronic brain ischemia using Semax and hopantenic acid comprehensive administration

Journal of Education, Health and Sport, 2023
The relevance and importance of treating patients with ischemic brain lesions are indisputable. Chronic ischemic processes in the brain occur much more frequently than acute cerebral circulation disorders, leading to prolonged disability and being the ...
V. Kirchev
doaj   +1 more source