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Lymphatic drainage of the brain and the pathophysiology of neurological disease
Acta Neuropathologica, 2008There are no conventional lymphatics in the brain but physiological studies have revealed a substantial and immunologically significant lymphatic drainage from brain to cervical lymph nodes. Cerebrospinal fluid drains via the cribriform plate and nasal mucosa to cervical lymph nodes in rats and sheep and to a lesser extent in humans.
Weller, Roy O. +3 more
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The role of the meningeal lymphatic in the brain clearing
Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 2019Here in ex vivo (confocal imaging) and in vivo (optical coherent tomography) experiments on adult mice, we clearly demonstrate that the meningeal lymphatic drainage is an important mechanism for the brain clearing that might be also pathway for the brain clearing from metabolites and waste products that requests further detailed studies.
Maria Klimova +9 more
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Our current understanding of the lymphatics of the brain and spinal cord
Clinical Anatomy, 2018The lymphatic system, segregated from the blood vascular system, is an essential anatomical route along which interstitial fluid, solutes, lipids, immune cells, and cellular debris, are conveyed. However, the way these mechanisms operate within the cranial compartment is mostly unknown.
Dupont, Graham +6 more
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Investigating the Lymphatic Drainage of the Brain: Essential Skills and Tools
2017In this chapter we describe in detail the surgical and imaging techniques employed for the study of the anatomical routes of drainage of cerebrospinal fluid (CSF) and interstitial fluid (ISF) from the brain. The types of tracers, sites of injection, and volumes injected are crucial.
Albargothy, Nazira J. +6 more
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Lymphology
The brain's lymphatic system is comprised of a glymphatic-meningeal-cervical lymphatic vessel pathway. The study of its mechanism and pathophysiology in neurodegenerative disease has been one of the most exciting topics in basic and translational neuroscience of the last decade.
M J, Bartlett +4 more
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The brain's lymphatic system is comprised of a glymphatic-meningeal-cervical lymphatic vessel pathway. The study of its mechanism and pathophysiology in neurodegenerative disease has been one of the most exciting topics in basic and translational neuroscience of the last decade.
M J, Bartlett +4 more
openaire +1 more source
[Immunologic significance of lymphatic drainage of the brain].
Bulletin de l'Academie nationale de medecine, 1997Despite the evidence for immunological reactions in the human CNS, in viral encephalitis and in multiple sclerosis, connections between the brain and the immune system are poorly understood. In rodents, tracers injected into the interstitial fluid of the brain drain to the cervical lymph nodes by perivascular pathways in the brain and nasal lymphatics.
R O, Weller +3 more
openaire +1 more source
Lymphatic drainage of the brain
The Biomedical & Life Sciences Collection, 2023openaire +1 more source
Brain and other central nervous system tumor statistics, 2021
Ca-A Cancer Journal for Clinicians, 2021, Jill Barnholtz-Sloan, Carol Kruchko
exaly