Results 231 to 240 of about 1,655,573 (298)

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

The Thoracic Lymphatic Vasculature: Interorgan Strategies to Achieve an Optimal Tissue Function. [PDF]

Compr Physiol
Negrini D, Solari E, Marcozzi C, Moriondo A.   +3 more
europepmc   +1 more source

Time‐Dependent Efficacy of Lymphaticovenous Anastomosis in Secondary Lymphedema: A Rabbit Model Study

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Secondary lymphedema was induced in New Zealand White rabbits by popliteal lymph node excision and afferent lymphatic vessel ligation, causing sustained hind limb swelling. LVA was performed immediately or after 4, 8, or 12 weeks. Patency was verified intraoperatively by microsuturing and postoperatively by indocyanine green (ICG) lymphangiography ...
Ping Zhao, Wenzhao Liu, Mingqiang Liu, Jintao Yang, Sen Li, Xun Li   +5 more
wiley   +1 more source

Meningeal lymphatics as a therapeutic target for neurodegenerative disorders. [PDF]

Transl Neurodegener
Feng Y, Wang S, Xia H, Jiang X, Wu M, Pan S, Song W.   +6 more
europepmc   +1 more source

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

Occurrence of Extramedullary Relapses in Pediatric Acute Lymphoblastic Leukemia After Treatment With Blinatumomab

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz, Martin Ebinger, Michaela Döring, Markus Mezger, Ursula Holzer, Rupert Handgretinger, Peter Lang, Manon Queudeville   +7 more
wiley   +1 more source

The glymphatic system and glioblastoma. [PDF]

Brain
Soumbasis A, Ueno A, Elliott D, Lama S, Edwards S, Starreveld YP, Zhang Y, Federico P, Sutherland GR, LeVan P, Poon CC.   +10 more
europepmc   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, Volume 15, Issue 37, 9 October 2026.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Multimodal evidence for bone lymphatics in skeletal health and repair.

Cell
Yang Y, Zhang Y, Shi Y, Jain S, Joseph JD, Singh A, Chen J, Ramasamy SK, Kusumbe AP.   +8 more
europepmc   +1 more source