Results 1 to 10 of about 190,897 (242)

Protocol to generate murine organotypic brain cultures for drug screening and evaluation of anti-metastatic efficacy

STAR Protocols, 2023
Summary: Organotypic brain cultures are short-term assays that phenotypically and functionally recapitulate brain metastatic cells in vivo. Here, we present a protocol to generate murine organotypic brain cultures for drug screening.
Lucía Zhu, Lauritz Miarka, Patricia Baena, María Perea-García, Manuel Valiente   +4 more
doaj   +1 more source

Multifocal and pathologically-confirmed brain metastasis complete response to trastuzumab deruxtecan

CNS Oncology, 2022
Antibody–drug conjugates have transformed the treatment of HER2+ breast and other cancers. Unfortunately, the CNS remains a sanctuary site for many such patients in part due to poor macromolecule penetration across the blood–brain tumor barrier ...
Nelson S Moss, Umberto Tosi, Bianca D Santomasso, Kathryn Beal, Shanu Modi   +4 more
doaj   +1 more source

HER2‐positive breast cancer brain metastasis: A new and exciting landscape

Cancer Reports, 2022
Background Brain metastases (BrM) incidence is 25% to 50% in women with advanced human epidermal growth factor receptor 2 (HER2)‐positive breast cancer.
Alexandra S. Zimmer, Amanda E. D. Van Swearingen, Carey K. Anders   +2 more
doaj   +1 more source

Intracranial Outcomes of De Novo Brain Metastases Treated With Osimertinib Alone in Patients With Newly Diagnosed EGFR-Mutant NSCLC

JTO Clinical and Research Reports, 2023
Introduction: Patients with EGFR-mutant NSCLC have a high incidence of brain metastases. The EGFR-directed tyrosine kinase inhibitor osimertinib has intracranial activity, making the role of local central nervous system (CNS)-directed therapies, such as ...
Brandon S. Imber, MD, MA, Ryka Sehgal, MD, Rachel Saganty, MD, Anne S. Reiner, MPH, A. Turan Ilica, MD, Emily Miao, PharmD, Bob T. Li, MD, Gregory J. Riely, MD, Helena A. Yu, MD, Katherine S. Panageas, DrPH, Robert J. Young, MD, Luke R.G. Pike, MD, DPhil, Nelson S. Moss, MD   +12 more
doaj   +1 more source

Growth exponents reflect evolutionary processes and treatment response in brain metastases

npj Systems Biology and Applications, 2023
Tumor growth is the result of the interplay of complex biological processes in huge numbers of individual cells living in changing environments. Effective simple mathematical laws have been shown to describe tumor growth in vitro, or simple animal models
Beatriz Ocaña-Tienda, Julián Pérez-Beteta, Juan Jiménez-Sánchez, David Molina-García, Ana Ortiz de Mendivil, Beatriz Asenjo, David Albillo, Luis A. Pérez-Romasanta, Manuel Valiente, Lucía Zhu, Pedro García-Gómez, Elisabet González-Del Portillo, Manuel Llorente, Natalia Carballo, Estanislao Arana, Víctor M. Pérez-García   +15 more
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A Need for More Molecular Profiling in Brain Metastases

Frontiers in Oncology, 2022
As local disease control improves, the public health impact of brain metastases (BrM) continues to grow. Molecular features are frequently different between primary and metastatic tumors as a result of clonal evolution during neoplasm migration ...
Erica Shen, Erica Shen, Amanda E. D. Van Swearingen, Amanda E. D. Van Swearingen, Meghan J. Price, Ketan Bulsara, Roeland G. W. Verhaak, Roeland G. W. Verhaak, Roeland G. W. Verhaak, César Baëta, César Baëta, Brice D. Painter, Brice D. Painter, Zachary J. Reitman, Zachary J. Reitman, April K. S. Salama, April K. S. Salama, Jeffrey M. Clarke, Jeffrey M. Clarke, Carey K. Anders, Carey K. Anders, Peter E. Fecci, Peter E. Fecci, C. Rory Goodwin, C. Rory Goodwin, Kyle M. Walsh, Kyle M. Walsh   +26 more
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A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

EMBO Molecular Medicine, 2022
We report a medium‐throughput drug‐screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing in situ.
Lucía Zhu, Diana Retana, Pedro García‐Gómez, Laura Álvaro‐Espinosa, Neibla Priego, Mariam Masmudi‐Martín, Natalia Yebra, Lauritz Miarka, Elena Hernández‐Encinas, Carmen Blanco‐Aparicio, Sonia Martínez, Cecilia Sobrino, Nuria Ajenjo, Maria‐Jesus Artiga, Eva Ortega‐Paino, Raúl Torres‐Ruiz, Sandra Rodríguez‐Perales, RENACER, Riccardo Soffietti, Luca Bertero, Paola Cassoni, Tobias Weiss, Javier Muñoz, Juan Manuel Sepúlveda, Pedro González‐León, Luis Jiménez‐Roldán, Luis Miguel Moreno, Olga Esteban, Ángel Pérez‐Núñez, Aurelio Hernández‐Laín, Oscar Toldos, Yolanda Ruano, Lucía Alcázar, Guillermo Blasco, José Fernández‐Alén, Eduardo Caleiras, Miguel Lafarga, Diego Megías, Osvaldo Graña‐Castro, Carolina Nör, Michael D Taylor, Leonie S Young, Damir Varešlija, Nicola Cosgrove, Fergus J Couch, Lorena Cussó, Manuel Desco, Silvana Mouron, Miguel Quintela‐Fandino, Michael Weller, Joaquín Pastor, Manuel Valiente, Adolfo de la Lama‐Zaragoza, Lourdes Calero‐Felix, Concepcion Fiaño‐Valverde, Pedro David Delgado‐López, Antonio Montalvo‐Afonso, Mar Pascual‐Llorente, Ángela Díaz‐Piqueras, SH Nam‐Cha, Cristina Barrena López, Gerard Plans Ahicart, Elena Martínez‐Saez, Santiago Ramón y Cajal, Pilar Nicolás   +64 more
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The NG2-glia is a potential target to maintain the integrity of neurovascular unit after acute ischemic stroke

Neurobiology of Disease, 2023
The neurovascular unit (NVU) plays a critical role in health and disease. In the current review, we discuss the critical role of a class of neural/glial antigen 2 (NG2)-expressing glial cells (NG2-glia) in regulating NVU after acute ischemic stroke (AIS).
Xiaoyan Hu, Panpan Geng, Xiaoyun Zhao, Qian Wang, Changqing Liu, Chun Guo, Wen Dong, Xinchun Jin   +7 more
doaj   +1 more source

Single-Cell Sequencing Reveals the Novel Role of Ezh2 in NK Cell Maturation and Function

Frontiers in Immunology, 2021
Natural killer (NK) cells are lymphocytes primarily involved in innate immunity and exhibit important functional properties in antimicrobial and antitumoral responses.
Minghang Yu, Minghang Yu, Ziyang Su, Xuefeng Huang, Xuefeng Huang, Xi Wang, Xi Wang   +6 more
doaj   +1 more source

Factors Associated With New-Onset Seizures Following Stereotactic Radiosurgery for Newly Diagnosed Brain Metastases

Advances in Radiation Oncology, 2022
Purpose: Stereotactic radiosurgery (SRS) is a highly effective therapy for newly diagnosed brain metastases. Prophylactic antiepileptic drugs are no longer routinely used in current SRS practice, owing to a perceived low overall frequency of new-onset ...
Emily C. Lerner, BA, Ethan S. Srinivasan, BS, Gloria Broadwater, MS, Aden P. Haskell-Mendoza, MS, Ryan M. Edwards, BA, David Huie, MD, Eugene J. Vaios, MD, MBA, Scott R. Floyd, MD, PhD, Justus D. Adamson, PhD, Peter E. Fecci, MD, PhD   +9 more
doaj   +1 more source