Results 11 to 20 of about 190,897 (242)

A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures

npj Precision Oncology, 2021
PARP inhibitors are approved for the treatment of solid tumor types that frequently harbor alterations in the key homologous recombination (HR) genes, BRCA1/2.
Miklos Diossy, Zsofia Sztupinszki, Judit Borcsok, Marcin Krzystanek, Viktoria Tisza, Sandor Spisak, Orsolya Rusz, Jozsef Timar, István Csabai, Janos Fillinger, Judit Moldvay, Anders Gorm Pedersen, David Szuts, Zoltan Szallasi   +13 more
doaj   +1 more source

Systemic Therapy Type and Timing Effects on Radiation Necrosis Risk in HER2+ Breast Cancer Brain Metastases Patients Treated With Stereotactic Radiosurgery

Frontiers in Oncology, 2022
BackgroundThere is a concern that HER2-directed systemic therapies, when administered concurrently with stereotactic radiosurgery (SRS), may increase the risk of radiation necrosis (RN).
Christine Park, Evan D. Buckley, Amanda E. D. Van Swearingen, Amanda E. D. Van Swearingen, Will Giles, James E. Herndon, James E. Herndon, John P. Kirkpatrick, John P. Kirkpatrick, John P. Kirkpatrick, Carey K. Anders, Carey K. Anders, Scott R. Floyd, Scott R. Floyd   +13 more
doaj   +1 more source

Brain metastasis

Nature Reviews Cancer, 2019
Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and melanoma, is associated with poor survival outcomes and poses distinct clinical challenges. The brain microenvironment, with its unique cell types, anatomical structures, metabolic constraints and immune environment, differs drastically from microenvironments of ...
Adrienne Boire, Priscilla K. Brastianos, Livia Garzia, Manuel Valiente   +3 more
openaire   +3 more sources

Reactive Astrocytes in Brain Metastasis

Frontiers in Oncology, 2017
Brain metastasis, the secondary growth of malignant cells within the central nervous system (CNS), exceeds the incidence of primary brain tumors (i.e., gliomas) by tenfold and are seemingly on the rise owing to the emergence of novel targeted therapies ...
David Wasilewski, Neibla Priego, Coral Fustero-Torre, Manuel Valiente   +3 more
doaj   +1 more source

Perspective on nanochannels as cellular mediators in different disease conditions

Cell Communication and Signaling, 2018
Tunnelling nanotubes (TNTs), also known as membrane nanochannels, are actin-based structures that facilitate cytoplasmic connections for rapid intercellular transfer of signals, organelles and membrane components.
Eshna Jash, Peeyush Prasad, Naveen Kumar, Taruna Sharma, Aaron Goldman, Seema Sehrawat   +5 more
doaj   +1 more source

Brain metastasis from ovarian carcinoma: Analysis of eight cases from a single radiotherapy center

Taiwanese Journal of Obstetrics & Gynecology, 2020
Objective: Brain metastasis from epithelial ovarian carcinoma (EOC) is rarely seen having rate of 1–3% with very poor prognosis. Studies on brain metastatic EOC is limited with low number of participants.
Zumrut Bahat, Vildan Altunayoglu Cakmak, Ertugrul Cakir   +2 more
doaj   +1 more source

Brain metastasis prognostic nomograms and brain metastasis velocity: a narrative review [PDF]

Chinese Clinical Oncology, 2022
To provide a review of the current status of predictive nomograms and brain metastasis velocity (BMV) in the prognostication of brain metastasis outcomes.Statistical analyses have been used for many years in an attempt to predict clinical outcomes of brain metastasis patients.
Mohammed, Abdulhaleem, Jimmy, Ruiz, Christina, Cramer, Fei, Xing, Hui Wen, Lo, Jing, Su, Michael D, Chan   +6 more
openaire   +2 more sources

ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells

Experimental Hematology & Oncology, 2023
Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in addition to reducing survival.
Julien Cicero, Sarah Trouvilliez, Martine Palma, Gaetan Ternier, Laurine Decoster, Eloise Happernegg, Nicolas Barois, Alexandre Van Outryve, Lucie Dehouck, Roland P. Bourette, Eric Adriaenssens, Chann Lagadec, Cagatay Mehmet Tarhan, Dominique Collard, Zied Souguir, Elodie Vandenhaute, Grégory Maubon, François Sipieter, Nicolas Borghi, Fumitaka Shimizu, Takashi Kanda, Paolo Giacobini, Fabien Gosselet, Nathalie Maubon, Xuefen Le Bourhis, Isabelle Van Seuningen, Caroline Mysiorek, Robert-Alain Toillon   +27 more
doaj   +1 more source

Outcomes of brain metastasis in high-grade bone and soft tissue sarcoma: An analysis of clinicopathological characteristics and survival data

Rare Tumors, 2021
Brain metastases in sarcoma are exceedingly rare, with few published series documenting ranges from 1% to 8%. This study investigated the outcomes of sarcoma patients with brain metastases using a population-based analysis.
Charles A Gusho, Alan T Blank, Marta Batus   +2 more
doaj   +1 more source

Brain metastasis and treatment [PDF]

F1000Prime Reports, 2014
Despite major therapeutic advances in the management of patients with systemic malignancies, management of brain metastases remains a significant challenge. These patients often require multidisciplinary care that includes surgical resection, radiation therapy, chemotherapy, and targeted therapies. Complex decisions about the sequencing of therapies to
Ahluwalia, Manmeet S., Vogelbaum, Michael V., Chao, Samuel T., Mehta, Minesh M.   +3 more
openaire   +2 more sources