Results 151 to 160 of about 19,404 (259)

Development of a highly differentiated rat brain organoid model for exploring glioblastoma invasion dynamics and therapy. [PDF]

Neuro Oncol
Zhou W, Martinez-Garcia E, Sarnow K, Kanli G, Nazarov PV, Li Y, Schwab SG, Meiser J, Jaeger C, Mieczkowski J, Misztak A, Thorsen FA, Grützmann K, Mihaljevic B, Van Loon B, Hossain JA, Zhang Y, Xue Z, Li W, Moreino SS, Golebiewska A, Niclou SP, Bjørås M, Tardito S, Joesph JV, Lunavat TR, Saed HS, Bahador M, Han M, Fabian C, Miletic H, Li X, Dittmar G, Keunen O, Klink B, Wang J, Bjerkvig R.   +36 more
europepmc   +1 more source

Engineering programmable peptide hydrogels for chronic refractory wounds: A mechanism‐driven framework

BMEMat, EarlyView.
To break the self‐perpetuating pathology of chronic wounds, we propose a mechanism‐driven engineering framework for peptide‐based hydrogels. This review elucidates a hierarchical strategy—from molecular design to intelligent, multi‐functional systems—that enables these programmable biomaterials to dynamically intervene in key pathological loops and ...
Xiaoyu Lv, Xinyi Chao, Jiamin Zhang, Jianfeng Liu   +3 more
wiley   +1 more source

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, EarlyView.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

Endocrine-disrupting effects of environmental BPS and PFOS on human brain organoid development. [PDF]

Front Endocrinol (Lausanne)
Di Credico A, Gaggi G, Bibbò S, Blenkinsop TA, Di Baldassarre A, Ghinassi B.   +5 more
europepmc   +1 more source

Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric developmental safety assessment presents distinct challenges in drug development. Children undergo dynamic changes in organ systems and drug disposition pathways during development, and drug‐related effects may be delayed or manifested differently than in adults.
Gilbert J. Burckart, Gelareh Abulwerdi, Christin L. Daniels, Calib Choi, Rebecca Racz, Jean‐Pierre Valentin, Kristin Ardlie, Nicholas Tatonetti, Susan Laffan, Marjory Moreau, Will Redfern, Lang Li, James J. Hickman, Rajanikanth Madabushi, Bhagwat Prasad, Lynne Yao, Paul B. Watkins   +16 more
wiley   +1 more source

Morphodynamics of human early brain organoid development. [PDF]

Nature
Jain A, Gut G, Sanchis-Calleja F, Tschannen R, He Z, Luginbühl N, Zenk F, Chrisnandy A, Streib S, Harmel C, Okamoto R, Santel M, Seimiya M, Holtackers R, Rohland JK, Jansen SMJ, Lutolf MP, Camp JG, Treutlein B.   +18 more
europepmc   +1 more source

Three‐dimensional observation of the muscle–tendon integration process in mouse embryos

Developmental Dynamics, EarlyView.
Abstract Background Muscle–tendon integration is a crucial step in the morphogenesis of the vertebrate locomotion system. As the limb muscle and tendon progenitor cells derive from distinct embryonic origin, their integration requires precise mutual positioning.
Ramu Sagasaki, Anzu Taniguchi, Shunsuke Oka, Mizuki Mishima, Yuki Yamasaki, Yutaro Kawa, Saundra Schlesinger, Ryo Fujita, Chisa Shukunami, Hiroshi Asahara, Masafumi Inui   +10 more
wiley   +1 more source

All-in-one generation and multiomic profiling of human whole brain organoid on a millifluidic plate. [PDF]

Mater Today Bio
Zhao W, Wang Y, Chen T, Shen M, Wang J, Huang X, Zhu L, Yu T, Zhang Z, Yang Y, Liu M, Wang D, Huang W, Hu R, Chen P.   +14 more
europepmc   +1 more source

Nanophotonic Biosensors and the Paradigm of Trans‐Scale Autonomous Bio‐Integrated Diagnostics for Addressing Health Complexities

Electron, EarlyView.
Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary, Harsh Sable, Sonu Sonu, Lakshita Phor, Reddicherla Umapathi, Pradeep Bhadola   +5 more
wiley   +1 more source

Brain organoids: are they for real?

Frontiers in Science, 2023
openaire   +1 more source