Results 161 to 170 of about 26,891 (293)

Editorial: Brain Organoids: Modeling in Neuroscience [PDF]

Frontiers in Cellular Neuroscience, 2020
Matteo Bordoni, Alysson R. Muotri, Alysson R. Muotri, Cristina Cereda   +3 more
openaire   +3 more sources

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Immunohistochemistry (Brain organoids) v1

This protocol describes how to prepare brain organoids slides and how to perform immunostainings to study the expression and localization of target proteins in this 3D model.
openaire   +1 more source

Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects

Animal Models and Experimental Medicine, EarlyView.
Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu, Jiaqi Chen, Zhonghui Li, Jiamin Zhou, Hui Zhang, Yujia Yu, Feng Cheng, Jie Bao, Chunhan Feng, Xiangqu Yu, Zhao Xia, Rao Ding, Xiang Li   +12 more
wiley   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

A home for brain organoids [PDF]

Nature Methods, 2018
openaire   +2 more sources

Protocol for quality control screening of brain organoid morphology. [PDF]

STAR Protoc
Chiaradia I, Boulanger J, Elmkvist SB, Larsen MR, Lancaster MA.   +4 more
europepmc   +1 more source

Brain organoid technology in melanoma metastasis to the brain. [PDF]

Melanoma Manag
Rabinowitz G, Schuldt BR, Ji AL, Gulati N.   +3 more
europepmc   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Development of a highly differentiated rat brain organoid model for exploring glioblastoma invasion dynamics and therapy. [PDF]

Neuro Oncol
Zhou W, Martinez-Garcia E, Sarnow K, Kanli G, Nazarov PV, Li Y, Schwab SG, Meiser J, Jaeger C, Mieczkowski J, Misztak A, Thorsen FA, Grützmann K, Mihaljevic B, Van Loon B, Hossain JA, Zhang Y, Xue Z, Li W, Moreino SS, Golebiewska A, Niclou SP, Bjørås M, Tardito S, Joesph JV, Lunavat TR, Saed HS, Bahador M, Han M, Fabian C, Miletic H, Li X, Dittmar G, Keunen O, Klink B, Wang J, Bjerkvig R.   +36 more
europepmc   +1 more source