Results 181 to 190 of about 26,891 (293)

RNA-binding activity of PHGDH drives amyloid-beta production in a human brain organoid model of sporadic Alzheimer's disease. [PDF]

Proc Natl Acad Sci U S A
Chen J, Xu M, Liu Y, Hadi F, Xue S, Chien S, Zhong S.   +6 more
europepmc   +1 more source

Integrative genomic and spatial transcriptomic analysis elucidates the oligodendrocyte‐mediated etiology of epileptic cortical thinning

Epilepsia Open, EarlyView.
Abstract Objective Focal epilepsy is characterized by progressive cortical thinning, particularly within limbic structures; however, whether this atrophy reflects acquired seizure‐induced damage or shared genetic predisposition remains unresolved. Methods We integrated genome‐wide association study (GWAS) summary statistics from the ILAE Consortium ...
Dingyuan Zhang, Qianqian Zhang, Guangming Li, Lingting Yu, Yanling Ma, Xiaoli Hong, Yujie Kui, Shanshan Cai, Jianguang Sun, Zechao Zhu   +9 more
wiley   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

The Ethics of Human Brain Organoid Transplantation in Animals. [PDF]

Neuroethics, 2023
Kataoka M, Gyngell C, Savulescu J, Sawai T.   +3 more
europepmc   +1 more source

Predominance of In‐Field Recurrence After Radiotherapy for Sinonasal Cancer: A Single‐Center Retrospective Study

Head &Neck, EarlyView.
ABSTRACT Background Sinonasal malignancies (SNM) are rare, heterogeneous tumors with poor prognosis. There is an unmet need to improve treatment outcomes. Despite advances in imaging and molecular classification, optimal curative radiotherapy (RT) strategies remain undefined.
M. de Ridder, L. J. van de Velde, T. de Bie, R. van Noortwijk, C. P. J. Raaijmakers, E. H. Voormolen, W. W. Braunius, R. de Bree, G. E. Breimer, L. A. Devriese, E. J. Smid, J. A. Rijken   +11 more
wiley   +1 more source

Modest Neurodevelopment Impacts of <italic>APOE4</italic> in a Human Brain Organoid Model of Low-Grade SARS-CoV-2 Infection. [PDF]

Dev Neurosci
Muniz-Perez A, Meyer-Acosta KK, Boyana S, Ponnala V, McMahon CL, Aruk A, Elizalde A, Hsieh J.   +7 more
europepmc   +1 more source

Brain organoid models of Huntington's disease shift the focus towards neurodevelopment. [PDF]

Dis Model Mech
Xu W, Prigione A.
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Brain organoid models of SZT2-related disease reveal an overproduction of outer radial glial cells through mTORC1 activation. [PDF]

Sci Rep
Sato E, Nakamura Y, Fujimoto M, Shimada IS, Iwaki T, Ieda D, Negishi Y, Hattori A, Kato Y, Saitoh S.   +9 more
europepmc   +1 more source