Results 201 to 210 of about 19,404 (259)

Expert consensus on clinical trial design guidelines for FLASH radiotherapy

Precision Radiation Oncology, EarlyView.
• FLASH radiotherapy has emerged as a transformative technology due to the underlying FLASH effect. • As FLASH radiotherapy moves toward clinical application, establishing standardized trial design principles is critical. • This expert consensus provides a roadmap for rigorous clinical evaluation of FLASH radiotherapy, accelerating safe translation of ...
Hui Luo, Chen Cheng, Chengliang Yang, Bing Li, Jiandong Zhang, Jinbo Yue, Zhaoyang Lou, Hui Liu, Jing Cai, Hong Ge   +9 more
wiley   +1 more source

Axially multifocal metalens for 3D volumetric photoacoustic imaging of neuromelanin in live brain organoid. [PDF]

Sci Adv
Barulin A, Barulina E, Oh DK, Jo Y, Park H, Park S, Kye H, Kim J, Yoo J, Kim J, Bak G, Kim Y, Kang H, Park Y, Park JC, Rho J, Park B, Kim I.   +17 more
europepmc   +1 more source

Human Prostate Cell Lines: Derivation, Molecular Characteristics and Appropriate Use

The Prostate, EarlyView.
ABSTRACT Background Research on prostate cancer and benign prostatic hyperplasia depends on a small number of immortalized human cell lines established between 1977 and 2001, most of them from advanced metastatic disease. The cell lines differ from one another in androgen receptor status, prostate‐specific antigen secretion, p53 status, karyotype and ...
Hamza Abohamra, Keenau Mark Pearce
wiley   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

Antiretroviral drug therapy does not reduce neuroinflammation in an HIV-1 infection brain organoid model. [PDF]

J Neuroinflammation
Martinez-Meza S, Premeaux TA, Cirigliano SM, Friday CM, Michael S, Mediouni S, Valente ST, Ndhlovu LC, Fine HA, Furler O'Brien RL, Nixon DF.   +10 more
europepmc   +1 more source

Electrochemical and Biological Evaluation of Patterned TiO2@TiC‐Nanowires for Bio‐Interface Electrode

Small, EarlyView.
This study introduces a room‐temperature process to fabricate patterned TiO2@TiC core–shell nanowires, merging the biocompatibility of TiO2‐NWs with the high conductivity of TiC. Through sputtering pressure and time modulation, the nanowires morphology and electrochemical properties are tuned, enabling enhanced capacitance, stability, and guided ...
Roaa Sait, Shofarul Wustoni, Nabeel Aslam, Camelia Florica, Andrea Diaz‐Gaxiola, Valentina‐Elena Musteata, Mohammed K. Drad, Stephen Ghandour, Georgian Melinte, Yaping Zhang, Mohammed Nejib Hedhili, Ahad Ali Syed, Menouer Saidani, Shahryar Khattak, Imed Eddine‐Gallouzi, Sahika Inal, Hala Aljawhari   +16 more
wiley   +1 more source

Advancing insights into virus-induced neurodevelopmental disorders through human brain organoid modelling. [PDF]

Expert Rev Mol Med
Crawford G, Soper O, Kang E, Berg DA.
europepmc   +1 more source

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

Human Brain Organoid Research and Applications: Where and How to Meet Legal Challenges? [PDF]

J Bioeth Inq
Kataoka M, Lee TL, Sawai T.
europepmc   +1 more source

3D Nanoprinted Structures Promote Robust Integration of Brain Organoids into Topography‐Guided Neuronal Networks

Small, EarlyView.
Dedicated cultivation platforms facilitate the implementation of brain organoids in guided neuronal networks. Fabrication is enabled by two‐photon polymerization‐based 3D nanoprinting (3DN) and allows for cultivation in standard 12‐well plates. Fine features, namely slopes, funnels, rods, steps, and walls, facilitate and promote organoid positioning ...
Malte Siegmund, Tobias Müller, Emma Wollesen, Kim Krieg, Jack Muse, Jan Hahn, Maya Luongo, Wolfgang J. Parak, Ole Pless, Robert Zierold, Robert H. Blick   +10 more
wiley   +1 more source