Results 221 to 230 of about 26,891 (293)

Axially multifocal metalens for 3D volumetric photoacoustic imaging of neuromelanin in live brain organoid. [PDF]

Sci Adv
Barulin A, Barulina E, Oh DK, Jo Y, Park H, Park S, Kye H, Kim J, Yoo J, Kim J, Bak G, Kim Y, Kang H, Park Y, Park JC, Rho J, Park B, Kim I.   +17 more
europepmc   +1 more source

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Protocol for the generation of cultured cortical brain organoid slices. [PDF]

STAR Protoc
Petersilie L, Kafitz KW, Neu LA, Heiduschka S, Le S, Prigione A, Rose CR.   +6 more
europepmc   +1 more source

Morphodynamics of human early brain organoid development

, 2023
Jain A, Gut G, Sanchis-Calleja F, Okamoto R, Streib S, He Z, Zenk F, Santel M, Seimiya M, Holtackers R, Jansen SMJ, Camp JG, Treutlein B.   +12 more
europepmc   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

Antiretroviral drug therapy does not reduce neuroinflammation in an HIV-1 infection brain organoid model. [PDF]

J Neuroinflammation
Martinez-Meza S, Premeaux TA, Cirigliano SM, Friday CM, Michael S, Mediouni S, Valente ST, Ndhlovu LC, Fine HA, Furler O'Brien RL, Nixon DF.   +10 more
europepmc   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

Application Potential of Organoid Technology for Neural Repair of Post‐Stroke Pain

Organ Medicine, EarlyView.
Miao Lin, Xiaodong Chu, Rong Zeng
wiley   +1 more source

Exploring the Impact of RNU4‐2 Defects on Neurodevelopmental Disorders in a Korean Population

Clinical Genetics, EarlyView.
Among 15 450 Korean individuals, noncoding RNU4‐2 variants, primarily the recurrent de novo n.64_65insT, make up 0.72% of neurodevelopmental disorders. Modeling and RNA‐seq suggest U4/U6 disruption and abnormal 5′ splice‐site selection, supporting routine use of WGS analysis for reanalyzing unresolved cases. ABSTRACT Neurodevelopmental disorders (NDDs)
Juhyeon Hong, Seungbok Lee, Soo Yeon Kim, Taekeun Kim, Woong‐Hee Shin, Sesong Jang, Ji‐Hwan Park, Dongmin Jang, Gunwoo Park, Jong Ho Cha, Jae So Cho, Anna Cho, Hunmin Kim, Hyewon Woo, Jon Soo Kim, Byung Chan Lim, Ji Eun Lee, Myungshin Kim, Chong Kun Cheon, Jungmin Choi, Jong‐Hee Chae   +20 more
wiley   +1 more source

Advancing insights into virus-induced neurodevelopmental disorders through human brain organoid modelling. [PDF]

Expert Rev Mol Med
Crawford G, Soper O, Kang E, Berg DA.
europepmc   +1 more source