Results 221 to 230 of about 19,404 (259)

Polarizing brain organoids

Nature Biotechnology, 2019
Human brain organoids are endowed with regional topography using engineered signaling centers.
Yuki Miura, Sergiu P. Pașca
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Organoid technology for brain and therapeutics research [PDF]

CNS Neuroscience and Therapeutics, 2017
SummaryBrain is one of the most complex organs in human. The current brain research is mainly based on the animal models and traditional cell culture. However, the inherent species differences between humans and animals as well as the gap between organ level and cell level make it difficult to study human brain development and associated disorders ...
Shu-Na Wang, Chao-Yu Miao, Ding-Feng Su
exaly   +3 more sources

Microinstrumentation for Brain Organoids

Advanced Healthcare Materials
AbstractBrain organoids are three‐dimensional aggregates of self‐organized differentiated stem cells that mimic the structure and function of human brain regions. Organoids bridge the gaps between conventional drug screening models such as planar mammalian cell culture, animal studies, and clinical trials.
Devan Patel, Saniya Shetty, Chris Acha, Itzy E. Morales Pantoja, Alice Zhao, Derosh George, David H. Gracias   +6 more
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Assembling human brain organoids

Science, 2019
Three-dimensional assembloids can be used to study human development and ...
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Interdisciplinary approaches to brain organoid biology

Folia Pharmacologica Japonica, 2023
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been widely used as materials for regenerative medicine and for modeling development and disease because of their pluripotency to differentiate into all cell types of the body.
Tomoki, Kodera, Fumitaka, Osakada
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Brain organoid-on-a-chip to create multiple domains in forebrain organoids

2023
Abstract Brain organoids are three-dimensionally reconstructed brain tissue derived from pluripotent stem cells in vitro. 3D tissue cultures have opened new avenues for exploring development and disease modeling. However, some physiological conditions, including signaling gradients in 3D cultures, have not yet been easily achieved. Here,
Yuan-Chen Tsai, Hajime Ozaki, Ango Morikawa, Kaori Shiraiwa, Andy Prosvey Pin, Aya Galal Salem, Kenneth Akady Phommahasay, Bret Kiyoshi Sugita, Christine Hein Vu, Saba Mamoun Hammad, Ken-ichiro Kamei, Momoko Watanabe   +11 more
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Brain organoids get vascularized

Nature Biotechnology, 2018
Transplantation of cerebral organoids into the mouse brain overcomes some limitations of in vitro systems.
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Brain Organoid Computing for Artificial Intelligence

2023
Abstract Brain-inspired hardware emulates the structure and working principles of a biological brain and may address the hardware bottleneck for fast-growing artificial intelligence (AI). Current brain-inspired silicon chips are promising but still limit their power to fully mimic brain function for AI computing. Here,
Hongwei, Cai, Zheng, Ao, Chunhui, Tian, Zhuhao, Wu, Hongcheng, Liu, Jason, Tchieu, Mingxia, Gu, Ken, Mackie, Feng, Guo   +8 more
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Brain organoids and brain disease organoids modeling in the age of artificial intelligence

Cell Organoid
Abstract The human brain governs bodily functions with exceptional complexity, yet neuroscience research is hindered by limited access to authentic human tissues, restricted availability of region-specific specimens, and a lack of physiologically relevant experimental models. Brain organoids and disease-specific
Jianfei Long, Xinxin Han
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