Results 191 to 200 of about 26,891 (293)

Focused Ultrasound‐Induced Mechanical Ablation Affects the Carbohydrate Metabolism of Residual/Peri‐Focally Localized Glioblastoma Cells

International Journal of Cancer, EarlyView.
Glioblastoma (GBM) is highly aggressive and therapy‐resistant, warranting exploration of novel treatment strategies, among them mechanical high‐intensity focused ultrasound (mFUS), which holds significant promise for tumor ablation. The present study examined mFUS‐induced changes specifically in carbohydrate metabolism, which affects vulnerability to ...
Frieda Bayler, Jonna Holler, Jacqueline Clüver, Levi Johanning, Dana Hellmold, Nils Oliver Schröder, Jessica Nojszewski, Hajrullah Ahmeti, Carolin Kubelt‐Kwamin, Michael Synowitz, Janka Held‐Feindt   +10 more
wiley   +1 more source

Brain Organoid Transplantation: A Comprehensive Guide to the Latest Advances and Practical Applications-A Systematic Review. [PDF]

Cells
Shen YP, Kokaia Z.
europepmc   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Navigating Brain Organoid Maturation: From Benchmarking Frameworks to Multimodal Bioengineering Strategies. [PDF]

Biomolecules
Huang J, Zhu Y, Tang J, Liu Y, Lu M, Zhang R, Sun AX.   +6 more
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Cellular transplantation and gene therapy. [PDF]

, 1993
Ildstad, ST, Ricordi, C, Starzl, TE
core  

A Murine Model of Glioblastoma Initiating Cells and Human Brain Organoid Xenograft for Photodynamic Therapy Testing. [PDF]

Int J Mol Sci
Mosteiro A, Diao D, Bedia C, Pedrosa L, Caballero GA, Aldecoa I, Mallo M, Solé F, Sevilla A, Ferrés A, Cabrera G, Muñoz-Tudurí M, Centellas M, Pineda E, Jiménez ÀS, González Sánchez JJ.   +15 more
europepmc   +1 more source

Bile Acids as Selective Gatekeepers of Dietary Lipid Absorption: Mechanistic Insights and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Their work provides evidence in murine models that the bile acid pool may function as a tunable filter whose selectivity for different fatty acids depends on bile acid concentration and composition. This framework suggests a selective decoupling of the absorption of excessive saturated fatty acids (SFAs) from that of beneficial polyunsaturated
Hao Wang, Yue Yang, Yulong Zhang, Yinling Li, Xuemei Ma, Haitao Wang   +5 more
wiley   +1 more source

Expanding the neuroimmune research toolkit with in vivo brain organoid technologies. [PDF]

Dis Model Mech
Tian A, Bhattacharya A, Muffat J, Li Y.
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source