Results 191 to 200 of about 19,404 (259)

Modest Neurodevelopment Impacts of <italic>APOE4</italic> in a Human Brain Organoid Model of Low-Grade SARS-CoV-2 Infection.

Dev Neurosci
Muniz-Perez A, Meyer-Acosta KK, Boyana S, Ponnala V, McMahon CL, Aruk A, Elizalde A, Hsieh J.   +7 more
europepmc   +1 more source

A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring. [PDF]

Internet Things (Amst)
Voitiuk K, Seiler ST, de Melo MP, Geng J, van der Molen T, Hernandez S, Schweiger HE, Sevetson JL, Parks DF, Robbins A, Torres-Montoya S, Ehrlich D, Elliott MAT, Sharf T, Haussler D, Mostajo-Radji MA, Salama SR, Teodorescu M.   +17 more
europepmc   +1 more source

The Gut–Brain Axis in Parkinson's Disease: From Clinical Observation toward Mechanism‐Based Precision Medicine

Movement Disorders, EarlyView.
Abstract Gastrointestinal dysfunction is increasingly recognized as a core feature of Parkinson's disease (PD), affecting quality of life, nutrition, medication response, and potentially the earliest stages of pathogenesis. This perspective traces the evolution of the gut from a neglected source of non‐motor symptoms to a central component of ...
Filip Scheperjans, Per Borghammer, Ronald F. Pfeiffer, Silke Appel‐Cresswell, Ali Keshavarzian   +4 more
wiley   +1 more source

Correction for Chen et al., RNA-binding activity of PHGDH drives amyloid-beta production in a human brain organoid model of sporadic Alzheimer's disease. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Advancing next-generation brain organoid platforms for investigating traumatic brain injury from repeated blast exposures. [PDF]

Front Bioeng Biotechnol
Bar-Kochba E, Carneal CM, Alphonse VD, Timm AC, Ernlund AW, Rodriguez CL, Morales Pantoja IE, Smirnova L, Hartung T, Merkle AC.   +9 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Brain organoid methodologies to explore mechanisms of disease in progressive multiple sclerosis. [PDF]

Front Cell Neurosci
Simões-Abade MBC, Patterer M, Nicaise AM, Pluchino S.   +3 more
europepmc   +1 more source

Patient iPSC‐derived astrocytes reveal impaired homeostasis and reactive‐like features in propionic acidemia

The Journal of Pathology, EarlyView.
Abstract Propionic acidemia (PA) is a neurometabolic disorder caused by propionyl‐CoA carboxylase deficiency with frequent neurological involvement, yet cell‐type‐specific mechanisms remain poorly defined. We established human induced pluripotent stem cell (iPSC)‐derived astrocytes (iAs) from patients harboring PCCA or PCCB mutations and investigated ...
Irene González‐Garnacho, Mar Álvarez, Francisco Zafra, Pilar Rodríguez‐Pombo, Lourdes R Desviat, Eva Richard   +5 more
wiley   +1 more source

Protocol for the generation of cultured cortical brain organoid slices. [PDF]

STAR Protoc
Petersilie L, Kafitz KW, Neu LA, Heiduschka S, Le S, Prigione A, Rose CR.   +6 more
europepmc   +1 more source

Morphodynamics of human early brain organoid development

, 2023
Jain A, Gut G, Sanchis-Calleja F, Okamoto R, Streib S, He Z, Zenk F, Santel M, Seimiya M, Holtackers R, Jansen SMJ, Camp JG, Treutlein B.   +12 more
europepmc   +1 more source