Results 141 to 150 of about 2,545,594 (299)
Reclaiming Anatomy as Method: From Morphological Reasoning to Clinical Relevance
Clinical Anatomy, EarlyView.ABSTRACT In recent decades, molecular biology and omics technologies have profoundly reshaped biomedical research, with genomics, proteomics, and other high‐throughput approaches dominating scientific agendas and funding priorities. Within this molecular paradigm, however, the anatomical sciences face an epistemic and institutional tension: morphology,
Katia Cortese, Marco Frascio
wiley +1 more source
Multiscale Comparative Analyses of OVB-Organoids and Cerebral Organoids
CellsOrganoid technology is critical for studying human brain development, but existing single-organoid culture systems fail to simulate inter-organ interactions (e.g., optic vesicle–brain) in embryogenesis.
Jingyi Yang +3 more
doaj +1 more source
Generation, interrogation, and future applications of microglia-containing brain organoids
Neural Regeneration ResearchBrain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and function.
J. Di Stefano +7 more
semanticscholar +1 more source
Three‐dimensional observation of the muscle–tendon integration process in mouse embryos
Developmental Dynamics, EarlyView.Abstract Background Muscle–tendon integration is a crucial step in the morphogenesis of the vertebrate locomotion system. As the limb muscle and tendon progenitor cells derive from distinct embryonic origin, their integration requires precise mutual positioning.
Ramu Sagasaki +10 more
wiley +1 more source
Bioengineering & Translational MedicineSelf‐organizing brain organoids provide a promising tool for studying human development and disease. Here we created human forebrain organoids with stable and homogeneous expression of channelrhodopsin‐2 (ChR2) by generating AAVS1 safe harbor locus ...
Soojung Hong +4 more
doaj +1 more source
Neural Regeneration ResearchThe brain is the most complex human organ, and commonly used models, such as two-dimensional-cell cultures and animal brains, often lack the sophistication needed to accurately use in research.
Raquel Coronel +10 more
doaj +1 more source
Electron, EarlyView.Physics‐driven advances in optical nanobiosensors for rapid, miniaturized, and point‐of‐care diagnostics for next‐generation decentralized and personalized healthcare based on sensor intelligence. ABSTRACT Public health emergencies and the escalating burden of chronic diseases necessitate a paradigm shift from centralized laboratory testing to rapid ...
Vishal Chaudhary +5 more
wiley +1 more source
WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy
Epilepsia, EarlyView.Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara +7 more
wiley +1 more source
Brain organoid maturation and implantation integration based on electrical signals input
Journal of Advanced ResearchIntroduction: Brain organoids are believed to be able to regenerate impaired neural circuits and reinstate brain functionality. The neuronal activity of organoids is considered a crucial factor for restoring host function after implantation. However, the
Xiao-Hong Li +11 more
doaj +1 more source