Results 1 to 10 of about 835,261 (172)

Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: A Longitudinal Study in a Macaque Model of Parkinson's Disease

Advanced Science, 2022
Parkinson's disease (PD) evolves over an extended and variable period in humans; years prior to the onset of classical motor symptoms, sleep and biological rhythm disorders develop, significantly impacting the quality‐of‐life of patients.
Florence Wianny, Kwamivi Dzahini, Karim Fifel, Charles Robert Eden Wilson, Agnieszka Bernat, Virginie Dolmazon, Pierre Misery, Camille Lamy, Pascale Giroud, Howard Michael Cooper, Kenneth Knoblauch, Emmanuel Procyk, Henry Kennedy, Pierre Savatier, Colette Dehay, Julien Vezoli   +15 more
doaj   +1 more source

Dopamine modulates the retinal clock through melanopsin-dependent regulation of cholinergic waves during development

BMC Biology, 2023
Background The mammalian retina contains an autonomous circadian clock that controls various aspects of retinal physiology and function, including dopamine (DA) release by amacrine cells. This neurotransmitter plays a critical role in retina development,
Chaimaa Kinane, Hugo Calligaro, Antonin Jandot, Christine Coutanson, Nasser Haddjeri, Mohamed Bennis, Ouria Dkhissi-Benyahya   +6 more
doaj   +1 more source

Theoretical foundations of studying criticality in the brain [PDF]

Theoretical foundations of studying criticality in the brain. Network Neuroscience 2022; 6 (4): 1148-1185, 2023
Criticality is hypothesized as a physical mechanism underlying efficient transitions between cortical states and remarkable information processing capacities in the brain. While considerable evidence generally supports this hypothesis, non-negligible controversies persist regarding the ubiquity of criticality in neural dynamics and its role in ...
arxiv   +1 more source

Liver organoids in domestic animals: an expected promise for metabolic studies

Veterinary Research, 2021
The liver is one of the most important organs, both in terms of the different metabolic processes (energy, lipid, ferric, uric, etc.) and of its central role in the processes of detoxification of substances of food origin or noxious substances (alcohol ...
Camille Baquerre, Guillaume Montillet, Bertrand Pain   +2 more
doaj   +1 more source

The broad edge of synchronisation: Griffiths effects and collective phenomena in brain networks [PDF]

Phil. Trans. R. Soc. A.380: 20200424 (2022), 2021
Many of the amazing functional capabilities of the brain are collective properties stemming from the interactions of large sets of individual neurons. In particular, the most salient collective phenomena in brain activity are oscillations, which require the synchronous activation of many neurons. Here, we analyse parsimonious dynamical models of neural
arxiv   +1 more source

Potentiel des organoïdes cérébraux comme modèles d’étude des neuropathologies chez les animaux domestiques

INRAE Productions Animales, 2023
Le cerveau est un organe complexe et tout modèle pour l'étudier dans ses aspects normaux et pathologiques devient un outil de choix en neurobiologie. La maîtrise et la diffusion de protocoles permettant le développement d'organoïdes cérébraux ont ouvert
Bertrand PAIN , Noémie AURINE, Théo LA ROSA, Camille BAQUERRE, Muriel COULPIER   +4 more
doaj   +1 more source

Epigenetic status of H19/IGF2 and SNRPN imprinted genes in aborted and successfully derived embryonic stem cell lines in non-human primates

Stem Cell Research, 2016
The imprinted genes of primate embryonic stem cells (ESCs) often show altered DNA methylation. It is unknown whether these alterations emerge while deriving the ESCs. Here we studied the methylation patterns of two differentially methylated regions (DMRs)
Florence Wianny, Thierry Blachère, Murielle Godet, Rémi Guillermas, Véronique Cortay, Pierre-Yves Bourillot, Annick Lefèvre, Pierre Savatier, Colette Dehay   +8 more
doaj   +1 more source

Exploring the Acquisition and Production of Grammatical Constructions Through Human-Robot Interaction with Echo State Networks

Frontiers in Neurorobotics, 2014
One of the principal functions of human language is to allow people to coordinate joint action. This includes the description of events, requests for action, and their organization in time.
Xavier eHinaut, Xavier eHinaut, Maxime ePetit, Maxime ePetit, Grégoire ePointeau, Grégoire ePointeau, Peter F Dominey, Peter F Dominey, Peter F Dominey   +8 more
doaj   +1 more source

Radial Migration Dynamics Is Modulated in a Laminar and Area-Specific Manner During Primate Corticogenesis

Frontiers in Cell and Developmental Biology, 2020
The orderly radial migration of cortical neurons from their birthplace in the germinal zones to their final destination in the cortical plate is a prerequisite for the functional assembly of microcircuits in the neocortex.
Veronique Cortay, Delphine Delaunay, Dorothée Patti, Elodie Gautier, Nathalie Doerflinger, Pascale Giroud, Kenneth Knoblauch, Cyril Huissoud, Cyril Huissoud, Henry Kennedy, Henry Kennedy, Colette Dehay   +11 more
doaj   +1 more source

The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage

Brain Sciences, 2023
Perinatal brain damage, one of the most common causes of lifelong impairment, is predominantly caused by a lack of oxygen and glucose during early development.
Denis Jagečić, Dražen Juraj Petrović, Iva Šimunić, Jasmina Isaković, Dinko Mitrečić   +4 more
doaj   +1 more source