Results 251 to 260 of about 965,485 (298)
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Science, 2022
A new drug is designed to hit an old target with increased ...
Roger, Reddel, Adel, Aref
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A new drug is designed to hit an old target with increased ...
Roger, Reddel, Adel, Aref
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The brain: A vulnerable target
Experimental Gerontology, 1997This article addresses the description of several endocrine-related functions of the brain. It has emerged that steroids and growth factors may influence brain functions, and that brain cells may metabolize sex steroids. The crosstalk between different types of brain cells (neurons, astrocytes, the LHRH (luteinizing hormone-releasing hormone) producing
L. Martini, R. C. Melcangi
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Brain‐targeting drug delivery systems
WIREs Nanomedicine and Nanobiotechnology, 2022AbstractBrain diseases, including neurodegenerative diseases, acute ischemic stroke and brain tumors, have become a major health problem and a huge burden on society with high morbidity and mortality. However, most of the current therapeutic drugs can only relieve the symptoms of brain diseases, and it is difficult to achieve satisfactory therapeutic ...
Peixin Liu, Chen Jiang
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Annual Review of Pharmacology and Toxicology, 2007
The central nervous system (CNS) is a sanctuary site and is protected by various barriers. These regulate brain homeostasis and the transport of endogenous and exogenous compounds by controlling their selective and specific uptake, efflux, and metabolism in the brain. Unfortunately, potential drugs for the treatment of most brain diseases are therefore
A G, de Boer, P J, Gaillard
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The central nervous system (CNS) is a sanctuary site and is protected by various barriers. These regulate brain homeostasis and the transport of endogenous and exogenous compounds by controlling their selective and specific uptake, efflux, and metabolism in the brain. Unfortunately, potential drugs for the treatment of most brain diseases are therefore
A G, de Boer, P J, Gaillard
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Ventilatory targets following brain injury
Current Opinion in Critical Care, 2023Purpose of review Recent studies have focused on identifying optimal targets and strategies of mechanical ventilation in patients with acute brain injury (ABI). The present review will summarize these findings and provide practical guidance to titrate ventilatory settings at the bedside, with a focus on managing potential brain-
Shaurya, Taran +2 more
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Targeted therapy for brain tumours
Nature Reviews Drug Discovery, 2004Although previously considered untreatable, brain tumours no longer carry the same prognosis as they did even a decade ago. Recent advances in drug delivery to the central nervous system have not only bypassed physiological constraints such as the blood–brain barrier, but have, in fact, changed the course of treatment for patients with malignant brain ...
Maciej S, Lesniak, Henry, Brem
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Brain Targets for Pain Control
Stereotactic and Functional Neurosurgery, 1998A variety of brain sites have been targeted for surgical treatment of intractable pain. Both ablative and chronic stimulation procedures have been reported to attenuate such pain. These targets include the thalamus and its projections, the periventricular gray, the cingulate cortex and the motor cortex.
K D, Davis +3 more
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Targeted Treatment of Brain Metastases
Current Neurology and Neuroscience Reports, 2017Brain metastases are the most common intracranial tumors in adults. Historically, the median survival after the diagnosis of brain metastases has been dismal and medical therapies had a limited role in the management of these patients.The advent of targeted therapy has ushered in an era of increased hope for patients with brain metastases.
Nicole, Shonka +2 more
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Pharmaceutical Targeting of the Brain
Current Pharmaceutical Design, 2016Besides being indispensable for the protection and nutrition of the central nervous system (CNS), blood-brain barrier (BBB)-forming cerebral endothelial cells (CECs) have a major role in hampering drugs to reach therapeutically relevant concentrations in the brain.
Krizbai István Adorján +7 more
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Molecular Medicine Today, 1998
Abstract Gene Therapy for Neurological Disorders and Brain Tumors edited by E.A. Chiocca and X.O. Breakefield, Humana Press, 1998.
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Abstract Gene Therapy for Neurological Disorders and Brain Tumors edited by E.A. Chiocca and X.O. Breakefield, Humana Press, 1998.
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