Results 11 to 20 of about 831,573 (301)
Nature Communications, 2023 Glioblastoma is an immunologically cold tumour, with poor CD8 + T cell infiltration and enrichment in immunosuppressive tumour-associated myeloid cells. Here, the authors generate a bispecific lipid nanoparticle targeting CD47 and PD-L1, combined with a ...
Peng Zhang +18 more
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Advancement of science, 2022 Surgeons face challenges in intraoperatively defining margin of brain tumors due to its infiltrative nature. Extracellular acidosis caused by metabolic reprogramming of cancer cells is a reliable marker for tumor infiltrative regions. Although the acidic
Ziyi Jin +14 more
semanticscholar +1 more source
Discover Oncology, 2023 Background Aberrant expression of Secretory Leukocyte Protease Inhibitor (SLPI) has been associated with human cancer growth and its suppression was identified as a potential target for anti-cancer drugs, particularly in colorectal cancer.
Zhijiang Wei +7 more
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Fluorescence-Guided Surgery: A Review on Timing and Use in Brain Tumor Surgery
Frontiers in Neurology, 2021 Fluorescence-guided surgery (FGS) allows surgeons to have improved visualization of tumor tissue in the operating room, enabling maximal safe resection of malignant brain tumors.
A. Schupper +6 more
semanticscholar +1 more source
Turning on the light for brain tumor surgery: A 5-aminolevulinic acid story
Neuro-Oncology, 2022 To aid surgeons in more complete and safe resection of brain tumors, adjuvant technologies have been developed to improve visualization of target tissue.
D. McCracken +5 more
semanticscholar +1 more source
Scientific Reports, 2022 Glioblastoma (GBM) is the most common primary brain tumor with a median survival under two years. Using in silico and in vitro techniques, we demonstrate heterogeneous expression of CD97, a leukocyte adhesion marker, in human GBM.
Michael M. Safaee +15 more
doaj +1 more source
Neurosurgical Focus, 2021 Indocyanine green (ICG) is a water-soluble dye that was approved by the FDA for biomedical purposes in 1956. Initially used to measure cardiocirculatory and hepatic functions, ICG's fluorescent properties in the near-infrared (NIR) spectrum soon led to ...
Clare W. Teng +6 more
semanticscholar +1 more source
Reducing the Cognitive Footprint of Brain Tumor Surgery
Frontiers in Neurology, 2021 The surgical management of brain tumors is based on the principle that the extent of resection improves patient outcomes. Traditionally, neurosurgeons have considered that lesions in “non-eloquent” cerebrum can be more aggressively surgically managed ...
N. Dadario +3 more
semanticscholar +1 more source
Reducing the burden of brain tumor surgery [PDF]
Acta Neurochirurgica, 2020 Abstract Background Even though the need has been challenged, admitting patients to an intensive care or medium care unit (ICU/MCU) after adult supratentorial tumor craniotomy remains common practice. We have introduced a “no ICU, unless” policy for tumor craniotomy patients and evaluate costs, complications, and length ...
Mark ter Laan +3 more
openaire +3 more sources
Proteomic analysis predicts anti-angiogenic resistance in recurred glioblastoma
Journal of Translational Medicine, 2023 Background Recurrence is common in glioblastoma multiforme (GBM) because of the infiltrative, residual cells in the tumor margin. Standard therapy for GBM consists of surgical resection followed by chemotherapy and radiotherapy, but the median survival ...
Hanwool Jeon +13 more
doaj +1 more source