Results 101 to 110 of about 80,558 (315)
Metalurgija, 2020 The article discusses the issues of fatigue fracture of steel structures and the method of increasing their strength through the use of reinforcing elements.
A. D. Mekhtiyev +5 more
doaj
Advanced Science, EarlyView.Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng +17 more
wiley +1 more source
Method of combating fatigue destruction of steel structures of mine hoisting machines
Metalurgija, 2020 The article presents the information of the identified defects of fatigue failure of steel structures of the brake mechanism of mine cable hoisting machines used to transport metallurgical coke from the mine to the surface.
A. D. Mekhtiyev +5 more
doaj
Brake tests to evaluate the human behaviour at different brake pedal characteristics [PDF]
-Brake-by-wire represents the replacement of traditional brake components such as pumps, hoses, fluids, brake boosters, and tandem master cylinders by electronic sensors and actuators.
Ball, Andrew +4 more
core
The Innovative Design of Rolling Stock Brake Elements [PDF]
, 2017 The paper deals with traffic safety in railway transport. The influence of the work of the braking system friction elements on braking performance is evaluated.
Juraj Gerlici +4 more
core +1 more source
Advanced Science, EarlyView.Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan +11 more
wiley +1 more source
Advanced Science, EarlyView.This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao +5 more
wiley +1 more source
Experimental investigation of the mean and turbulent flow characteristics at the exit of automotive vented brake discs [PDF]
, 2002 The paper reports on an experimental investigation of the mean and turbulent flow structure at the exit of vented automotive brake discs. The main goal is to obtain a deeper insight of the aero-thermal phenomena upon which the brake efficiency strongly ...
Perdichizzi, Antonio +2 more
core +1 more source
Advanced Science, EarlyView.Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak +6 more
wiley +1 more source