Results 81 to 90 of about 80,558 (315)

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

open access: yesAdvanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han   +20 more
wiley   +1 more source

An Intelligent Auxiliary Vacuum Brake System [PDF]

open access: yes, 2009
The purpose of this paper focuses on designing an intelligent, compact, reliable, and robust auxiliary vacuum brake system (VBS) with Kalman filter and self-diagnosis scheme.
Tong, Chia-Chang   +3 more
core  

Experimental investigation and modeling of brake squeal using simplified test rigs [PDF]

open access: yes, 2007
This paper presents a synopsis of recent investigations on brake squeal noise carried out on simplified experimental rigs. The common theme of the these works is that of approaching the study of squeal noise on experimental set-ups that are much simpler ...
A. Sestieri   +6 more
core   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

open access: yesAdvanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li   +8 more
wiley   +1 more source

A Comparative Statistical Analysis of Two Brake Emission Test Cycles

open access: yesAtmosphere
Non-exhaust emissions represent a growing share of traffic-related particulate matter and are increasingly addressed by regulatory frameworks. This study presents a comparison of two brake emission test cycles, the California Brake Dynamometer Cycle ...
Sampsa Martikainen   +6 more
doaj   +1 more source

Brake-Shoe [PDF]

open access: yes, 1916
Patent for an M.C.
Christensen, Jacob V. C. T.
core  

Self‐Powered Bearing Sensing and Real‐Time Fault Diagnosis Enabled by Non‐Invasive Triboelectric Sensors and Edge AI Acceleration

open access: yesAdvanced Science, EarlyView.
This study achieves the synergistic integration of self‐powered sensing and edge AI acceleration to establish a real‐time fault diagnosis system. The proposed TENG‐based self‐powered bearing sensor (NSE‐TBS) and FPGA‐accelerated edge AI framework fundamentally break through the inherent limitations of conventional monitoring systems, including complex ...
Kehui Zhu   +7 more
wiley   +1 more source

An Investigation into the Influence of the Contact Pressure Distribution at the Friction Pair Interface on Disc Brake Squeal [PDF]

open access: yes
The main purpose of this thesis is to investigate the dynamic centre of pressure during a noisy brake application. A novel technique is employed to measure the centre of pressure and contact pressure distribution between the disc/pad interfaces during ...
Ashraf, Naveed
core  

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

open access: yesAdvanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu   +8 more
wiley   +1 more source

Research on configuration management of civil aircraft brake control system software

open access: yesHangkong gongcheng jinzhan
The configuration management of civil aircraft brake control system plays a key role in the process of system design and development and airworthiness compliance verification.
LIU Li
doaj   +1 more source

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