Results 41 to 50 of about 2,125 (266)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Development and experimental study of new brake friction pairs for standard metro train

机车电传动, 2022
Based on the installation interface requirements and vehicle braking parameters of standard metro train friction pairs, the design development and experimental verification of new lightweight brake friction pairs were carried out through scheme design ...
GOU Qingbing, ZHANG Ning, MENG Fanhui, JIN Wenwei, TAN Dong, GAO Hongmei   +5 more
doaj  

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Research on Brake Disk Heat Dissipation Rib Arrangement Spacing for High-speed Railway Train

Chengshi guidao jiaotong yanjiu
Objective As the design speed of trains reaches 400 km/h level, the flow field environment under the train becomes more complex, highlighting the issues such as increased brake disc resistance and power consumption.
Yanli YAN, Haihao GU, Chun TIAN, Gengwei ZHAI   +3 more
doaj   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Effects of material properties on generation of brake squeal noise using finite element method

Latin American Journal of Solids and Structures
This research paper is concerned with the disc brake squeal problem for passenger cars. The aim of the present research is developing a finite element model of the disc brake assembly in order to improve understanding of the influence of Young's modulus ...
Ali Belhocine, Nouby Mahdi Ghazaly
doaj   +1 more source

Bicycle Disc Brake Thermal Performance: Combining Dynamometer Tests, Bicycle Experiments, and Modeling

Proceedings, 2020
High-power bicycle disc braking can create excessive temperatures and boiling brake fluid, resulting in performance degradation and damage. The goal of this work is to understand brake friction performance and thermal behavior for bicycle disc brakes.
Ioan Feier, Joseph Way, Rob Redfield
doaj   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Status and Prospect of Thermal Analysis of Train Brake Discs

机车电传动, 2019
Disc brake is widely used for railway vehicles and cars. During the braking process, the brake disc and the brake shoe generate a large amount of heat, which affects the braking performance, so it is necessary to perform thermal analysis on the brake ...
Yuecheng NIU, Fu LI, Xinrong LI, Jincheng LI   +3 more
doaj  

Material‐Encoded Synchronization of Immunogenic Cell Death With Adenosine A2A Receptor Blockade Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
A bismuth–copper diselenide–based nanoplatform (BSCS@PHY) coordinates immunogenic cell death with local A2A receptor blockade in 4T1 tumors. Thermally triggered shell melting exposes catalytic surfaces for glutathione depletion and chemodynamic ROS generation, while co‐delivering an A2AR antagonist and yeast‐wall adjuvant to enhance dendritic‐cell ...
Xiangting Yi, Hanlou Yang, Junting Huang, Pengfei Wu, Shiying Zhou, Zunde Liao, Min Han, Zishan Chen, Xiaoyu Huang, Nan Ma, Jie Zhou, Mingqiang Li, Yiling Zhong   +12 more
wiley   +1 more source