Results 51 to 60 of about 2,125 (266)
Advanced Science, EarlyView.Radioresistance arises partly from tumor cells evading cuproptosis via unknown defenses. This study reveals that the PRMT5‐VPS34 axis acts as a radiation‐activated anticuproptotic mechanism: PRMT5 methylates VPS34 at Arg174, recruiting USP10 to remove K48‐linked ubiquitination and prevent degradation.
Wei Chen +17 more
wiley +1 more source
Advanced Science, EarlyView.The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt +16 more
wiley +1 more source
Advanced Science, EarlyView.Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger +8 more
wiley +1 more source
Effect of Temperature Variations on Brake Squeal Characteristics in Disc Brake Systems
Engineering ProceedingsBrake squeal is an undesirable high-frequency noise caused by vibrations induced by friction in disc brake systems. The noise is strongly affected by temperature, as this influences the material properties of the friction pair and the dynamic behaviour ...
Akif Yavuz +3 more
doaj +1 more source
Defining the Temperature Change of the Brake Disc
Acta Technica Jaurinensis, 2018 In the article the thermal analysis of the brake disc and separator disc of a high performance power machine will be presented. As example an agricultural vehicle with weight of 30000 kg and maximum travel speed of 40 km/h will be taken.
Melinda Menyhártné Baracskai
doaj +1 more source
Leading the Pack: Next‐Generation Batteries for Humanoid Robotics
Advanced Science, EarlyView.Humanoid robots challenge traditional and anticipated energy technologies. Humanoid robot benchmarks of runtimes and energy demands for industry applications inform humanoid robot battery design choices at the cell level, pack level, and system level.
Matthew Bergschneider +6 more
wiley +1 more source
Applied SciencesAircraft brake discs undergo rapid temperature rises during braking, critically impacting safety, lifespan, and adjacent components. Therefore, it is particularly important to study the heat transfer mechanism during the braking process and predict the ...
Qingtang Meng +3 more
doaj +1 more source
Shape Optimization Design of Brake System Based on Opti Struct
Journal of Harbin University of Science and Technology, 2018 Due to friction heat effect or severe vibration and other factors，the performance of automobile brake is insufficient，according to natural frequency theory of the principle of dynamics，Firstly，the simulation software of OptiStruct is used to analyze the ...
CHEN Zai-fa
doaj +1 more source
Advanced Science, EarlyView.Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang +5 more
wiley +1 more source
MODAL AND THERMAL-MECHANICAL COUPLING ANALYSIS INAUTOMOTIVE DISC BRAKE MECHANISM
Jixie qiangdu, 2017 Brake pad is vibrating when it is friction contact with the brake disc surface in automotive disc brake mechanism.When the vibration rate is close to its natural frequency of the material.
BI HouHuang +3 more
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