Results 71 to 80 of about 24,756,041 (332)

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Research in Self-Boosting Disc Brakes for Heavy Vehicles

Механика машин, механизмов и материалов, 2008
Development of the analytical and practical scientific decisions is considered in the paper to increase the efficiency of automotive brake systems due to reduction of hysteresis losses and creation of perspective disk brake designs with self-boosting ...
D.V. Tretsiak
doaj  

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Brake tests to evaluate the human behaviour at different brake pedal characteristics [PDF]

-Brake-by-wire represents the replacement of traditional brake components such as pumps, hoses, fluids, brake boosters, and tandem master cylinders by electronic sensors and actuators.
Ball, Andrew, Mishra, Rakesh, Retzer, Hermann, Schmidt, Karsten, Stephenson, John   +4 more
core  

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

High-Transparency Linear Actuator Using an Electromagnetic Brake for Damping Modulation in Physical Human–Robot Interaction

Journal of Sensor and Actuator Networks
Enhancing the transparency of high-transmission-ratio linear actuators is crucial for improving the safety and capability of high-force robotic systems having physical contact with humans in unstructured environments.
Zahid Ullah, Thachapan Sermsrisuwan, Khemwutta Pornpipatsakul, Ronnapee Chaichaowarat, Witaya Wannasuphoprasit   +4 more
doaj   +1 more source

In Situ X‐Ray Tomography and Acoustic Emission Monitoring of Damage Evolution in C/C‐SiC Composites Fabricated by Liquid Silicon Infiltration

Advanced Science, EarlyView.
This study investigates how the internal structure of fiber‐reinforced ceramic composites affects their resistance to damage. By combining 3D X‐ray imaging with acoustic emission monitoring during mechanical testing, it reveals how silicon distribution influences crack formation.
Yang Chen, Renato S. M. Almeida, Stefan Flauder, Guillaume Couégnat, Kamen Tushtev, Jürgen Horvath, Peter Wriggers, Kurosch Rezwan   +7 more
wiley   +1 more source

Tractors brake systems [PDF]

, 2011
Tato bakalářská práce se zabývá přehledem součastné době používaných brzdových systémů traktorů. V práci jsou také popsány principy a konstrukce brzdových soustav.
Pazour, Martin
core  

Friction influence on brake squeal in disc and drum brakes using complex eigenvalue analysis [PDF]

Revista Brasileira de Ensino de Física
Brake noise, is a complex issue in automotive and industrial systems caused by friction-induced vibrations between the brake pad and disc. This noise impacts vehicle performance, accelerates component wear, and diminishes consumer satisfaction.
Romulo do Nascimento Rodrigues, Anderson Luiz Dias, Camilo Augusto Santos Costa, Roberto de Araujo Bezerra   +3 more
doaj   +1 more source