Results 211 to 220 of about 80,674 (255)
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Current Opinion in Clinical Nutrition and Metabolic Care, 2013
There is burgeoning evidence that branch chain amino acids (BCAAs) are biomarkers of metabolic, cardiovascular, renal and cerebrovascular disease. The purpose of this review is to summarize the current evidence in this area.Recent evidence demonstrates that BCAAs are associated with insulin resistance, type 2 diabetes, risk of cardiovascular disease ...
Bryan C, Batch +2 more
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There is burgeoning evidence that branch chain amino acids (BCAAs) are biomarkers of metabolic, cardiovascular, renal and cerebrovascular disease. The purpose of this review is to summarize the current evidence in this area.Recent evidence demonstrates that BCAAs are associated with insulin resistance, type 2 diabetes, risk of cardiovascular disease ...
Bryan C, Batch +2 more
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Branched-chain amino acids in cardiovascular disease
Nature Reviews Cardiology, 2022Research conducted in the past 15 years has yielded crucial insights that are reshaping our understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism and the molecular mechanisms underlying the close relationship between BCAA homeostasis and cardiovascular health. The rapidly evolving literature paints a complex picture, in
Robert W. McGarrah, Phillip J. White
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Branched-chain amino acid biosynthesis in fungi
Essays in Biochemistry, 2023Abstract Branched-chain amino acids (BCAAs)—isoleucine, leucine, and valine—are synthesized by fungi. These amino acids are important components of proteins and secondary metabolites. The biochemical pathway for BCAA biosynthesis is well-characterized in the yeast Saccharomyces cerevisiae.
Joel T. Steyer, Richard B. Todd
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2007
The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are synthesized by bacteria, fungi, and plants, but are essential for vertebrates including humans, who must receive them from their diet. The interest to construct overproducing industrial strains therefore stems from the need to supplement the food or feed with these amino acids ...
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The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are synthesized by bacteria, fungi, and plants, but are essential for vertebrates including humans, who must receive them from their diet. The interest to construct overproducing industrial strains therefore stems from the need to supplement the food or feed with these amino acids ...
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Branched chain amino acids as activators of branched chain ketoacid dehydrogenase
Biochemical and Biophysical Research Communications, 1978Abstract During purification of branched chain ketoacid dehydrogenase from Pseudomonas putida , large losses in enzyme activity occurred. Much of the activity was restored by the addition of a heat-treated, soluble fraction. The factor had a molecular weight less than 1000 and, of several potential effectors tested, the branched chain amino ...
C M, Roberts, J R, Sokatch
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The Branched-Chain Amino Acid Antagonism in Chicks
The Journal of Nutrition, 1978The effects of dietary supplements of branched-chain amino acids on growth, food consumption and metabolism in chicks were investigated. When an adequate diet contained 1.20, 1.60, 2.25, 3.75, or 5.00% leucine, increasing leucine content caused reduced food consumption and weight gains, coupled with impaired efficiency of food utilization.
T K, Smith, R E, Austic
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Evolution of the biosynthesis of the branched-chain amino acids
Origins of Life and Evolution of the Biosphere, 1995The origin of the biosynthetic pathways for the branched-chain amino acids cannot be understood in terms of the backwards development of the present acetolactate pathway because it contains unstable intermediates. We propose that the first biosynthesis of the branched-chain amino acids was by the reductive carboxylation of short branched chain fatty ...
A D, Keefe, A, Lazcano, S L, Miller
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Branched Chain Amino Acids in Metabolic Disease
Current Diabetes Reports, 2018Elevations in circulating branched chain amino acids (BCAAs) have gained attention as potential contributors to the development of insulin resistance and diabetes.Epidemiological evidence strongly supports this conclusion. Suppression of BCAA catabolism in adipose and hepatic tissues appears to be the primary drivers of plasma BCAA elevations.
Zoltan, Arany, Michael, Neinast
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Branched chain amino acids—What are they good for?
Clinical Nutrition, 1982Abstract From the above consideration it is apparent that the BCAA fulfill unique physiological functions in normal man. Thus, the BCAA constitute a principal source of nitrogen repletion in muscle tissue after the ingestion of a protein meal. In addition, the BCAA and leucine in particular have been implicated in the regulation of synthesis as well ...
L S, Eriksson, J, Wharen
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Branched-Chain Amino Acids and Brain Metabolism
Neurochemical Research, 2017This review aims to provide a historical reference of branched-chain amino acid (BCAA) metabolism and provide a link between peripheral and central nervous system (CNS) metabolism of BCAAs. Leucine, isoleucine, and valine (Leu, Ile, and Val) are unlike most other essential amino acids (AA), being transaminated initially in extrahepatic tissues, and ...
Justin E, Sperringer +2 more
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