Results 201 to 210 of about 81,174 (260)

Downsizing the Histone H3–H4 Quaternary Structure Into Foldamer Mimetics Yields High‐Affinity and Cell‐Permeable Ligands of ASF1

Angewandte Chemie, EarlyView.
We present a foldamer strategy to downsize the histone H3‐H4 quaternary structure into high‐affinity, medium‐sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide‐oligourea chimeras, designed through structure‐guided optimization and foldamer chemistry, recapitulate the natural H3‐H4 dimer binding mode while demonstrating plasma stability ...
Bo Li, Marie E. Perrin, Emma Maillard, Arthur Vitard, Gwenaëlle Moal, Johanne Mbianda, Christophe André, Magda Teixeira Nunes, Marie Vandamme, Guillaume Pinna, Céline Douat, Emmanuelle Thinon, Raphaël Guerois, Pierre Legrand, Gilles Guichard, Francoise Ochsenbein   +15 more
wiley   +1 more source

<i>Akkermansia muciniphila</i>'s <i>nifJ</i> gene enhances colostrum sIgA synthesis by branched-chain amino acid degradation to branched short-chain fatty acids. [PDF]

Gut Microbes
Wu D, Li F, Xiong W, Huang Z, Ma K, Huang J, Cai S, Deng J, Peng J, Xia X, Tan C.   +10 more
europepmc   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +1 more source

Integrating bioinformatics and machine learning to identify biomarkers of branched chain amino acid related genes in osteoarthritis. [PDF]

BMC Musculoskelet Disord
ZhaYang XZ, Chen YX, Hua WD, Bai ZL, Jin YP, Zhao XW, Liu QF, Meng ZD.   +7 more
europepmc   +1 more source

Remote Desaturation of Unprotected Amines and C─H Amination of Alkanes by Polarity‐Matched N‐Radical Cations

Angewandte Chemie, EarlyView.
Highly electrophilic N‐radical cations enable efficient and selective H‐atom transfer (HAT) of unprotected amines. In this exceedingly practical strategy, simple CuCl catalyzes an interrupted Hofmann–Löffler–Freytag (HLF) reaction to afford δ desaturated amines, aza‐heterocycles, and C─H aminated alkanes without protecting groups.
Pavitra Laohapaisan, Ross M. Dare, Meredith L. Rudich, Jacob J. A. Garwood, Siyuan Gong, R. Thomas Simons, David A. Nagib   +6 more
wiley   +1 more source

BCAT1 Activation Reprograms Branched-Chain Amino Acid Metabolism and Epigenetically Promotes Inflammation in Diabetic Retinopathy. [PDF]

Invest Ophthalmol Vis Sci
Wang J, Yin Z, Yang J, Sun S, Tang X, Zhang S, Wang YP, Wang H.   +7 more
europepmc   +1 more source

Crosslinking of Linear Polyimines Into Aminal‐Linked Porous Organic Polymers for C2 Hydrocarbon/Methane Separation

Angewandte Chemie, EarlyView.
Crosslinking of linear polyimines with aromatic diamines via nucleophilic addition converts nonporous polyimine precursors into aminal‐linked porous networks, offering a new strategy for synthesizing porous organic polymers. The resulting materials exhibit high C2 hydrocarbon adsorption capacity, excellent selectivity over CH4, and durable cyclic ...
Xuejie Li, Yayu Yan, Qiaohong Li, Michelle Åhlén, Chao Xu   +4 more
wiley   +1 more source

Author Response: The Future of Retinitis Pigmentosa Research: Unlocking the Potential of Branched-Chain Amino Acid Therapy. [PDF]

Transl Vis Sci Technol
Ikeda HO, Hasegawa T, Abe H, Amino Y, Nakagawa T, Tada H, Miyata M, Oishi A, Morita S, Tsujikawa A.   +9 more
europepmc   +1 more source

Inactivation of branched-chain amino acid uptake halts Staphylococcus aureus growth and induces bacterial quiescence within macrophages. [PDF]

PLoS Pathog
Moldovan A, Flannagan RS, Rühling M, Stelzner K, Hans C, Paprotka K, Kunz TC, Heinrichs DE, Rudel T, Fraunholz MJ.   +9 more
europepmc   +1 more source

Branched Chain Amino Acid Metabolism in Developmental Brain Injury: Putative Mechanisms and Therapeutic Potential.

Dev Neurosci
Cassidy MM, Yudkoff M, Ahrens-Nicklas RC, Cristancho AG.   +3 more
europepmc   +1 more source