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Branched-chain amino acids for hepatic encephalopathy
2003Hepatic encephalopathy may be caused by a decreased plasma ratio of branched-chain amino acids (BCAA) to aromatic amino acids. Treatment with BCAA may therefore have a beneficial effect on patients with hepatic encephalopathy.To evaluate the beneficial and harmful effects of BCAA for patients with hepatic encephalopathy.We identified trials through The
B, Als-Nielsen +3 more
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[The branched-chain amino acids].
Minerva gastroenterologica e dietologica, 2006Branched-chain amino acids (BCAA: leucine, isoleucine and valine) are not just structural constituents of proteins, but have ''pharmacologic'' properties, known for several years: BCAA are catabolized mainly in muscle; can be oxidized with energy production, being nitrogen donors for other amino acids; regulate protein synthesis and degradation ...
C, Chiarla +3 more
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Branched chain amino acids in heptatic encephalopathy
The American Journal of Surgery, 2002Early theories or hepatic encephalopathy focused on ammonia-driven disruption of the Krebs cycle and cellular energy production. The "false-neurotransmitter" theory directed attention toward the interactions of amino acids, metabolism, the blood-brain barrier and neurotransmission.
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Regulation of Branched-Chain Amino Acid Catabolism ,
The Journal of Nutrition, 1994Catabolism of the branched-chain amino acids is regulated in part at the step catalyzed by the branched-chain alpha-ketoacid dehydrogenase complex. Previous work suggests both short-term and long-term control mechanisms are involved in regulation of the kinase responsible for phosphorylation and inactivation of the branched-chain alpha-ketoacid ...
R A, Harris +3 more
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The metabolic role of branched-chain amino acids
Nutrition, 200214 C] leucine entering the tissue is decarboxylated in the diaphragm and that a considerable proportion is degraded even further. The percentages of decarboxylation for isoleucine (58%) and valine (31%) also were substantial. Addition of insulin brought about a small but consistent stimulation of leucine oxidation.
Herbert R, Freund, Menachem, Hanani
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Branched-chain amino acids as biomarkers in diabetes
Current Opinion in Clinical Nutrition and Metabolic Care, 2016Numerous human studies have consistently demonstrated that concentrations of branched-chain amino acids (BCAAs) in plasma and urine are associated with insulin resistance and have the quality to predict diabetes development. However, it is not known how altered BCAA levels link to insulin action and diabetes.
Pieter, Giesbertz, Hannelore, Daniel
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Brain metabolism of branched-chain amino acids
Glia, 1997The synthesis of brain glutamate requires an amino group donor that is efficiently transported into the brain and that is readily transaminated. The branched-chain amino acids (BCAA), particularly leucine, play this important role. The uptake of leucine across the blood-brain barrier is faster than any other amino acid.
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Transaminase of Branched Chain Amino Acids*
The Journal of Biochemistry, 1968Kenji Aki, Koichi Ogawa, Akira Ichihara
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Branched-Chain Amino Acids and Branched-Chain Ketoacids in Uremia
2015P, Fürst, A, Alvestrand, J, Bergström
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