Results 231 to 240 of about 148,302 (300)

BNB/NBN‐Phenalenyl‐2'‐deoxyuridines as a Fluorophore–Quencher Pair in DNA

Angewandte Chemie, EarlyView.
Two BN‐chromophore‐extended nucleosides containing electronically complementary BNB‐ and NBN‐doped phenalenyls were synthesised and incorporated into deoxyribonucleic acid (DNA) oligonucleotides. These chromophores act as an efficient fluorophore–quencher pair under aqueous conditions.
Sarah Lutz, Hermann Neitz, Michael Müller, Johannes Chorbacher, Konstantin A. Isenberg, Claudia Höbartner, Holger Helten   +6 more
wiley   +2 more sources

Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis. [PDF]

Nat Commun
Zhao H, Sun D, Wang S, Liu Y, Zhao X, Tian W, Dou X, Liu J, Xu J, Peng L, Sun S, Xia Y, Xu X, Wang C, Wang D, Zhao G, Wang X, Weng H, Ding F, Xing P, Zhang F, Liu S, Yan W, Tao L.   +23 more
europepmc   +1 more source

Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine‐Resistant Pancreatic Tumors

Advanced NanoBiomed Research, EarlyView.
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq, Sudip Kumar Dam, Doaha Awad, Punnya Anil Kumar Jeeja, Farzana Ferdous, Juan L. Vivero‐Escoto   +5 more
wiley   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, EarlyView.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources

Branched-chain amino acids induce hyperammonemia via gut-liver axis-mediated ammonia overproduction in laying hens. [PDF]

Anim Nutr
Jian H, Xu M, Liu F, Zhang L, Huang Q, Ma J, Zou X, Dong X.   +7 more
europepmc   +1 more source

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Quantum chemical study of molecular properties of small branched-chain amino acids in water. [PDF]

Amino Acids
Boča R, Rádiková Ž, Štofko J, Vranovičová B, Rajnák C.   +4 more
europepmc   +1 more source

Circulating branched-chain amino acids and the risk of major adverse cardiovascular events in the UK biobank. [PDF]

Front Endocrinol (Lausanne)
Sun W, Lin R, Li Y, Yao Y, Lu B, Yu Y.
europepmc   +1 more source

Short-term Physical Activity Reduces Metabolic-associated Steatohepatitis by Promoting the Degradation of Branched-chain Amino Acids in Skeletal Muscle. [PDF]

J Clin Transl Hepatol
Gao M, Li J, Zhang Y, Huang J, Chen J, Liao D, He S, Bi Q, Ji L, Du Y.   +9 more
europepmc   +1 more source

Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor–Donor Diazo Compounds

Angewandte Chemie International Edition, EarlyView.
Geminal difunctionalization of readily available building blocks provides rapid access to molecular complexity. This work introduces a strategy for installing two distinct functional groups on a carbonyl carbon by transforming it into a donor–donor diazo compound, enabling both batch and flow applications with broad solvent compatibility.
Vincent George, Aryaman Pattanaik, Daniel Maddox, Lukas M. Sigmund, Giovanna Mejia, Sara Pahlén, Simon O. Angerer, Maria Schmoll, Lisa Marie Schneider, Nidhal Selmi, Mikhail Kabeshov, Giulia Bergonzini, Julia Rehbein, Burkhard König   +13 more
wiley   +1 more source