Results 51 to 60 of about 70,776 (261)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Insights into Protein and Amino Acid Metabolism of Thermoanaerobacter mathranii

Fermentation
Few investigations have been carried out into the members of the genus Thermoanerobacter for protein and amino acid metabolism compared to carbohydrates, mostly due to the intense interest in bioethanol and biohydrogen in recent decades.
Sean Michael Scully, Clay A. Abraham, Johann Orlygsson   +2 more
doaj   +1 more source

Branched-Chain Amino Acids

, 2015
International Journal of Health, Animal Science and Food Safety, Vol 2, No 1s (2015): Proceeding of Veterinary and Animal Science ...
Ghiringhelli, Matteo, Acocella, Fabio, Bontempo, Valentino   +2 more
openaire   +2 more sources

Branched-Chain Amino Acids and Central Fatigue [PDF]

The Journal of Nutrition, 2006
An account of the tryptophan (Trp)-5-hydroxytryptamine (5-HT)-central fatigue theory is provided and an explanation of how oral administration of BCAAs can decrease fatigue on the basis of this theory is given. The rate-limiting step in the synthesis of 5-HT is the transport of Trp across the blood-brain barrier.
Eric A, Newsholme, Eva, Blomstrand
openaire   +2 more sources

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

Branched-chain amino acid metabolism in cancer

Current Opinion in Clinical Nutrition & Metabolic Care, 2018
The current review aims to provide an update on the recent biomedical interest in oncogenic branched-chain amino acid (BCAA) metabolism, and discusses the advantages of using BCAAs and expression of BCAA-related enzymes in the treatment and diagnosis of cancers.An accumulating body of evidence demonstrates that BCAAs are essential nutrients for cancer ...
Ananieva, Elitsa A., Wilkinson, Adam C.
openaire   +3 more sources

Biodegradable and Biocompatible Functional Polymers for Biomedical Applications

Advanced Functional Materials, EarlyView.
Biodegradable and biocompatible functional polymers integrate electrical, mechanical, and stimuli‐responsive functionalities while enabling programmed degradation under physiological conditions. This review introduces recent advances in conductive, shape‐memory, self‐healing, photocurable, and adhesive polymer systems, emphasizing material design ...
Won Bae Han, Shuvra Mondal, Sungkeun Han, Chan‐Hwi Eom, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +5 more
wiley   +1 more source

Silicone Phase Behavior Resolves the Softness–Surface Functionality Trade‐Off in Emerging Stretchable Electronics

Advanced Functional Materials, EarlyView.
Ultrasoft silicone elastomers often sacrifice surface functionality for mechanical compliance. In Mold Star, low‐molecular‐weight species form a dispersed phase that weakens the network and passivates the surface. Solvent extraction removes this phase, unexpectedly improving both extensibility and metallization performance, enabling conductive ...
Gloria M. D'Amaral, Rahaf Nafez Hussein, Tiago Carneiro Gomes, Jordan E. Nicholson, Lauren J. Renaud, Emily J. Addison, Simon Rondeau‐Gagné, Tricia Breen Carmichael   +7 more
wiley   +1 more source

Depletion of branched‐chain aminotransferase 2 (BCAT2) enzyme impairs myoblast survival and myotube formation

Physiological Reports, 2019
Much is known about the positive effects of branched‐chain amino acids (BCAA) in regulating muscle protein metabolism. Comparatively much less is known about the effects of these amino acids and their metabolites in regulating myotube formation.
Zameer N. Dhanani, Gagandeep Mann, Olasunkanmi A. J. Adegoke   +2 more
doaj   +1 more source

Role of symbiotic auxotrophy in the Rhizobium-legume symbioses.

PLoS ONE, 2010
BackgroundRhizobium leguminosarum bv. viciae mutants unable to transport branched-chain amino acids via the two main amino acid ABC transport complexes AapJQMP and BraDEFGC produce a nitrogen starvation phenotype when inoculated on pea (Pisum sativum ...
Jurgen Prell, Alexandre Bourdès, Shalini Kumar, Emma Lodwig, Arthur Hosie, Seonag Kinghorn, James White, Philip Poole   +7 more
doaj   +1 more source