Results 61 to 70 of about 2,748,091 (304)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Branched-chain amino acids linked to depression in young adults

Frontiers in Neuroscience, 2022
Depression is a heterogeneous mental health problem affecting millions worldwide, but a majority of individuals with depression do not experience relief from initial treatments. Therefore, we need to improve our understanding of the biology of depression.
Alyce M. Whipp, Alyce M. Whipp, Marja Heinonen-Guzejev, Kirsi H. Pietiläinen, Kirsi H. Pietiläinen, Irene van Kamp, Jaakko Kaprio, Jaakko Kaprio   +7 more
doaj   +1 more source

Branched Chain Amino Acids Protects Rat Mesangial Cells from High Glucose by Modulating TGF-β1 and BMP-7 [Corrigendum]

Diabetes, Metabolic Syndrome and Obesity, 2020
Zhang X, Liu D, He Y, Lou K, Zheng D, Han W. Diabetes Metab Syndr Obes. 2019;12:2433– 2440. The authors of this paper have advised of an error with affiliation 1.Read the original paper here 
Zhang X, Liu D, He Y, Lou K, Zheng D, Han W   +5 more
doaj  

The Role of Branched-Chain Amino Acids and Branched-Chain α-Keto Acid Dehydrogenase Kinase in Metabolic Disorders

Frontiers in Nutrition, 2022
Branched-chain amino acids (BCAAs), composed of leucine, isoleucine, and valine, are important essential amino acids in human physiology. Decades of studies have revealed their roles in protein synthesis, regulating neurotransmitter synthesis, and the ...
Chuang Du, Chuang Du, Chuang Du, Chuang Du, Wen-Jie Liu, Wen-Jie Liu, Wen-Jie Liu, Jing Yang, Jing Yang, Jing Yang, Shan-Shan Zhao, Shan-Shan Zhao, Shan-Shan Zhao, Shan-Shan Zhao, Hui-Xin Liu, Hui-Xin Liu, Hui-Xin Liu   +16 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Branched-chain amino acid metabolism in cancer

Current Opinion in Clinical Nutrition & Metabolic Care, 2018
The current review aims to provide an update on the recent biomedical interest in oncogenic branched-chain amino acid (BCAA) metabolism, and discusses the advantages of using BCAAs and expression of BCAA-related enzymes in the treatment and diagnosis of cancers.An accumulating body of evidence demonstrates that BCAAs are essential nutrients for cancer ...
Ananieva, Elitsa A., Wilkinson, Adam C.
openaire   +3 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Circulating Branched Chain Amino Acids and Cardiometabolic Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Branched chain amino acids (BCAAs) are essential for protein homeostasis, energy balance, and signaling pathways. Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including type ...
Keenan S. Fine, John T. Wilkins, Konrad T. Sawicki   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Insights into Protein and Amino Acid Metabolism of Thermoanaerobacter mathranii

Fermentation
Few investigations have been carried out into the members of the genus Thermoanerobacter for protein and amino acid metabolism compared to carbohydrates, mostly due to the intense interest in bioethanol and biohydrogen in recent decades.
Sean Michael Scully, Clay A. Abraham, Johann Orlygsson   +2 more
doaj   +1 more source