Results 71 to 80 of about 671,793 (294)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Laboratory-selected, probiotic Ligilactobacillus salivarius SBT2687 supplementation is associated with subjective knee symptoms and the gut microbiome in adults with pre-osteoarthritis: a randomized controlled trial in Japanese

Frontiers in Nutrition
IntroductionAlthough the gut microbiome is involved in the pathogenesis of knee osteoarthritis (OA), the effects of dietary supplementation remain controversial. Probiotics are a promising option for lifestyle management of inflammatory diseases.
Erina Ushizawa, Takehiko Yasueda, Ayatake Nakano, Tomohiro Sugino, Masahiro Fukuda, Hiroshi M. Ueno   +5 more
doaj   +1 more source

Consumer negativity towards brands: Brand hate or brand switch

Pressacademia, 2019
Purpose- Consumer negativity is one of crucial concepts for understanding and evaluating consumers in today’s world, since emotions play key role for consumer decision making. The study aims to examine consumer negativity with related concepts (brand hate and brand switch) in Turkey context.
PİNARBASİ, Fatih, ENGİNKAYA, Ebru
openaire   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Mehi River Lagoon in Mary Brand Park, Moree [picture] /

, 1994
Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an11306721 ...
Brand, Fiona MacDonald.
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Analysis of volatile flavor compounds in soaked plum wine based on HS-SPME-GC-MS [PDF]

Zhongguo niangzao
In this study, three kinds of soaked plum wine (whole fruit wine, pulp wine and kernel wine) were prepared by using whole fruit, pulp and kernel of plum as raw materials. The contents of ethyl carbamate (EC) and volatile aroma components in the wine were
CAO Hong, LIU Taotao*, SUN Xizhen, LI Qiang, XIONG Yaqing, WANG Zhe, YANG Wen, HUANG Xiuhua, NI Shugan
doaj   +1 more source