Results 111 to 120 of about 65,986 (255)

Impact of Molecular Alterations on Survival in Biliary Tract Cancers: A Retrospective Belgian Cohort Study

International Journal of Cancer, EarlyView.
ABSTRACT Biliary tract cancers (BTCs) are aggressive malignancies associated with a poor prognosis. Although molecular profiling is recommended to guide therapeutic decision‐making, real‐practice data on the prevalence and prognostic significance of genomic alterations in European BTC cohorts remain limited.
Jorine Arnouts, Léon C. van Kempen, Senada Koljenović, Helena Oliveres, Pieterjan Vanclooster, Hans Prenen, Caro De Weerdt, Siddharth Chhajlani, Geert Roeyen, Laure Sorber, Koen De Winne, Jonas Dahnoun, Greetje Vanhoutte, Timon Vandamme, Karen Zwaenepoel   +14 more
wiley   +1 more source

Impact of ovarian preservation on survival for premenopausal women with early‐stage endometrial carcinoma: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Up to 14% of women with early‐stage endometrial carcinoma (EEC) are diagnosed before menopause. Although ovarian preservation (OP) within surgical staging might avoid surgical menopause, its rate remains low in clinical practice, probably because the impact of OP on survival outcomes is unclear.
Antonio Raffone, Diego Raimondo, Daniele Neola, Manuela Maletta, Marisol Doglioli, Antonio Travaglino, Carlo Ronsini, Maria Giovanna Vastarella, Stefano Ferla, Francesco Cosentino, Pasquale De Franciscis, Renato Seracchioli, Luigi Cobellis   +12 more
wiley   +1 more source

Presence and prevalence of single nucleotide sequence polymorphisms in TP53 and BRCA2 genes as of cervical and ovarian cancers in women using hormonal contraceptives in Abuja, Nigeria

Journal of Public Health in Africa
Background: Cancer remains a major health burden in sub-Saharan Africa, characterised by high incidence and mortality rates as a result of late diagnosis, limited access to treatment and poor outcomes.
Omorinsola F. Odebiyi, Adedapo Kehinde, Mohammed S. Abdulsalami, Deborah M. Dibal   +3 more
doaj   +1 more source

Menopause hormone therapy in women with cardiovascular risk factors or established ischemic heart disease: A joint FIGO and WHF position paper

International Journal of Gynecology &Obstetrics, EarlyView.
Integrated approach to menopausal hormone therapy in women with cardiovascular risk factors or established ischemic heart disease, from early treatment initiation and risk stratification to individualized therapy, multidisciplinary follow‐up, and health‐system recommendations.
Chiara Benedetto, Martha Gulati, Suvarna S. Khadilkar, Angela H. E. M. Maas, Federica Frezet, Gláucia Maria Moraes de Oliveira, Andrea R. Genazzani, Hema Divakar, Athena Poppas, on behalf of the World Heart Federation (WHF) and the International Federation of Gynecology and Obstetrics (FIGO)   +9 more
wiley   +1 more source

Mutational analysis of BRCA 1 and BRCA 2 genes in Peruvian families with hereditary breast and ovarian cancer [PDF]

, 2017
Background Breast cancer is one of the most prevalent malignancies in the world. In Peru, breast cancer is the second cause of death among women. Five to ten percent of patients present a high genetic predisposition due to BRCA 1 and BRCA 2 germline ...
Guevara-Fujita, Maria, Acosta, Oscar, Buleje, Jose, Calderon, Gabriela, Murillo, Alexis, Araujo, Jhajaira M., Ponce, Jaime, Gomez, Henry L., Danos, Pierina, Pinto, Joseph A., Aguilar, Alfredo, Vigil, Carlos, Huaman, Francia D. P., Fujita, Ricardo, Castaneda, Carlos   +14 more
core  

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Uptake of BRCA Testing and Downstream Healthcare Utilization [PDF]

, 2019
Introduction: For almost 25 years, BRCA testing has been used to successfully personalize cancer risk for primary prevention, and can serve as model for integration of genetics and genomics into routine clinical care.
Kurz, Raluca Nedelcu
core   +1 more source

Timing Matters: A Meta‐Analysis of BREAST‐Q Administration in Tissue‐Expander and Implant‐Based Breast Reconstruction

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background BREAST‐Q is the most widely used patient‐reported outcome measure following breast reconstruction, yet no consensus exists on optimal timing or duration of administration. We analyzed BREAST‐Q follow‐up after implant‐based reconstruction, comparing direct‐to‐implant (DTI) and two‐stage tissue expander (TE), to determine how outcomes
Emanuella M. Brito, Isabel Bernal, Sean K. Park, Julia L. Armstrong, Natalia Correa, Anthony Pasarin, Anastasia Tousimis, Graham S. Schwarz, Martin I. Newman   +8 more
wiley   +1 more source

The value of common polymorphism mutations in Brca-1 and Brca-2 for breast cancer

, 2019
Amaç: Meme kanseri kadınlar arasında en sık görülen ve en fazla ölüme neden olan kanser tipidir. Meme kanseri oluşumunda birçok tümör supresör gen, onkogen ve DNA tamir genleri rol oynamaktadır. Tümör supresör genlerden BRCA-1-2 meme kanserine yol açtığı
Küçüköner, Mehmet, Akdeniz, Nadiye, Akkuzu, Mustafa Zanyar, İrtegün, Sevgi, Büyükbayram, Hüseyin, Kaplan, Muhammet Ali, Işıkdoğan, Abdurrahman, Urakçı, Zuhat   +7 more
core   +1 more source