Results 121 to 130 of about 65,986 (255)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Aspartyl‐tRNA synthetase 2 (DARS2), the mitochondrial enzyme responsible for aminoacylation of aspartyl‐tRNA, is traditionally known for its effect on protein synthesis. Recently, DARS2 is reported to be implicated in tumorigenesis. However, its specific effect on breast cancer (BC) is poorly understood.
Na Wang, Ming Huang
wiley +1 more source
Understanding Breast Cancer (BRCA) Mutations Through TikTok.
TikTok is one of the biggest social media platforms where people look for support, seek advice, and educate themselves through videos created by other users.
Lalovic, Tamara, Lalovic, Alexandar
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Prostate cancer remains a leading cause of cancer‐related mortality, largely driven by progression to metastatic castration‐resistant prostate cancer (mCRPC). Although poly(ADP‐ribose) polymerase inhibitors (PARPis) have improved outcomes in patients with homologous recombination repair (HRR) alterations, particularly in BRCA2‐mutated disease,
Jhen‐Hao Jhan +4 more
wiley +1 more source
Prevention of Early Onset of Breast Cancer With Ashwagandha
Molecular Carcinogenesis, EarlyView.ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm +2 more
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao +3 more
wiley +1 more source
Baicalin Induces Ferroptosis in Breast Cancer Through a Novel STAT3/HO‐1/GPX4 Regulatory Axis
Phytotherapy Research, EarlyView.BA inhibits STAT3 phosphorylation and activation in BC cells, accompanied by decreased expression of HO‐1 and GPX4. Reduced GPX4 activity impairs lipid peroxide clearance, promoting ROS accumulation and lipid peroxidation, which ultimately triggers ferroptosis and inhibits cell proliferation.
Tingting Guo +11 more
wiley +1 more source
Cooperative Regulation of Defect‐Mediated Molecular Recognition With Single‐Walled Carbon Nanotubes
Small, EarlyView.Defect‐mediated sensing in SWCNTs arises from the cooperative interplay of defect characteristics, density, heterogeneity, analyte properties, corona composition, and environment. Understanding these interconnected variables enables tunable fluorescence modulation, selective molecular recognition, ratiometric sensing, and sensitive detection in complex
Srestha Basu, Gili Bisker
wiley +1 more source
, 2019 Objectives: Genetic testing for a germline BRCA mutation in women with HER2-negative metastatic breast cancer (MBC) can guide targeted treatment with PARP inhibitors (e.g.
Tuffaha, H. +3 more
core +1 more source
Differentiating high‐ and low‐grade serous ovarian carcinoma using radiomics: a pilot study
Ultrasound in Obstetrics &Gynecology, EarlyView.ABSTRACT Objective To identify ultrasound‐based radiomics features capable of distinguishing between high‐grade serous ovarian carcinomas (HGSC) and invasive low‐grade serous ovarian carcinomas (LGSC), and to develop machine‐learning models that include radiomics features to discriminate between the two.
F. Ciccarone +17 more
wiley +1 more source
Perfil de pacientes con mutación BRCA y cáncer de mama
, 2017 Objective to study patients with breast cancer and BRCA 1 and / or 2 mutations. Material and methods We performed a retrospective study of 28 patients with breast cancer and BRCA 1 and/or 2 mutations between 2010 and 2016. Patients were excluded if their
Nuria Garrido González +11 more
core +1 more source