Results 141 to 150 of about 50,723 (266)

<i>BRCA</i> testing patterns in breast cancer over time in the United States: challenges and opportunities for improvement. [PDF]

Front Oncol
Mishkin K, Mandal E, Tallarigo D, Li Q, Casañas I Comabella C, Byrnes M, McCann KE, Moreno L, Rose D.   +8 more
europepmc   +1 more source

TCF/LEF family transcription factors: Molecular landscape and prognostic scoring in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
This study provides a comprehensive molecular landscape of TCF/LEF family transcription factors across 33 cancer types. We developed a TCF/LEF‐based prognostic score that correlates with immune infiltration, metabolic reprogramming and drug sensitivity, offering a robust transcriptomic signature for predicting patient survival and therapeutic response.
Zhengjun Yang, D. Q. Cai, Zhen Zhao, Zhixiang Jian, Mude Shi, Yajin Chen, Jueming Chen, Chunhua Qu, Diankui Cai   +8 more
wiley   +1 more source

Multimodal therapy for ovarian cancer with brain metastases diagnosed synchronously at the initial phase: case report of a long-term survivor with comprehensive literature review. [PDF]

Gynecol Oncol Rep
Arab W, Kassis NE, Khoury C, Mansour H, Chahine G, Atallah D.   +5 more
europepmc   +1 more source

Oestrogen receptor phosphorylation profiles and in silico PAM50 subtyping reflect sexual dimorphism in breast cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Breast cancer (BC) is most prevalent in females but also accounts for <1% of male cancer cases and 0.2% of male cancer‐related deaths. Distribution of histological subtypes, receptor status, and age of diagnosis varies based on sex, and a growing body of evidence supports sex‐specific molecular differences in BC.
Subarnarekha Chatterji, Aimee Diack, Marcin Szostok, Michael D Morgan, Valentina Silvestri, Laura Ottini, Cathy B Moelans, Paul J van Diest, Cigdem Selli, Andrew H Sims, Rasha Abu‐Eid, Valerie Speirs   +11 more
wiley   +1 more source

Prevalence of Homologous Recombination Deficiency and Treatment Patterns in Patients with Newly Diagnosed Advanced Ovarian Cancer in Bulgaria: A Real-World Cohort Study (VALIDATE). [PDF]

Medicina (Kaunas)
Arabadjiev J, Nikolov K, Koleva M, Shopov N, Tonev I, Krasteva R, Donev I, Yordanov V, Minchev V, Konsoulova A.   +9 more
europepmc   +1 more source

DDX21 Promotes Breast Cancer Growth and Metastasis via Stimulating RNAPII Elongation During Hypoxia

MedComm, Volume 7, Issue 7, July 2026.
DDX21 triggers CDK9 release from the 7SK RNP complex. DDX21‐CDK9 binding to HIFs drives transcriptional reprogramming during hypoxia. DDX21 enhances breast cancer progression and metastasis. Elevated DDX21 expression correlates with poor prognosis in breast cancer patients.
Guangqiang Li, Mingxia Deng, Leqing Zhu, Zhiwei Lei, Rong Guo, Xiong Liu, Renwang Chen, Xichun Xia, Qiong Wen, Yuanyuan Duan, Yan Chen, Zhinan Yin   +11 more
wiley   +1 more source

Upregulation of a Circular <i>BAX</i> Transcript in Breast Cancer Is Associated with Unfavorable Prognosis. [PDF]

Int J Mol Sci
Stafyla VK, Christodoulou S, Tsiakanikas P, Michalopoulos N, Danias N, Kokoropoulos P, Kontos CK, Arkadopoulos N.   +7 more
europepmc   +1 more source

Generative Artificial Intelligence and Large Language Models in Clinical Oncology

MedComm, Volume 7, Issue 7, July 2026.
By integrating multimodal data, including medical imaging, pathology, omics, and electronic health records, generative AI and LLMs support cancer diagnosis, treatment planning, and follow‐up management. These technologies also enhance physician–patient communication, improve personalized treatment strategies, and leverage intelligent agent automation ...
Yunfang Yu, Zhenhui Zhao, Zehua Wang, Ruichong Lin, Yujie Tan, Yongjian Chen, Ting Li, Daniel Baptista‐Hon, Xiaoxi Zhang, Chuan Wu, Man Tong, Lijun Zheng, Junyan Wu, Olivia Monteiro, Kang Zhang   +14 more
wiley   +1 more source

An 8-gene diabetes-related signature predicts survival and immunotherapy response in breast cancer. [PDF]

Clinics (Sao Paulo)
Jiang X, Yin J, Tong Y, Li J, Ren X, Zhu C.   +5 more
europepmc   +1 more source

ID3 deficiency alters chromatin accessibility at DSB sites and enhances vulnerability to HDAC inhibition

International Journal of Cancer, Volume 158, Issue 12, Page 3173-3186, 15 June 2026.
What's new? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte, Hossam Eldesouky, Julia Puchan, Sercan Öz, Elena Everatt, Ashish Goyal, Gianluca Sigismondo, Udo Oppermann, Christoph Plass, Dieter Weichenhan, Ali Bakr   +10 more
wiley   +1 more source