Results 151 to 160 of about 65,986 (255)

BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial

BACKGROUND Genetic testing to identify germline high-risk pathogenic variants in breast cancer susceptibility genes is increasingly part of the breast cancer diagnostic pathway.
Sophie Allen (8779097), Alice Garrett (439363), Lina Yuan (2489206), et al. (16062986), Suzanne MacMahon (14591984), Rosalind Way (16145273), Amy Taylor (102261), Mikel Valganon-Petrizan (19441585), Helena Harder (7809323), Monica Hamill (17788637), Subin Choi (2186788), Bethany Torr (15174361), Grace Kavanaugh (17788640), Valerie Jenkins (4460407), Rochelle Gold (19441588), Chris Jones (25458)   +15 more
core  

The PRIME trial: An investigator‐initiated, multicentre, phase II study of the poly(ADP‐ribose) polymerase inhibitor olaparib in isocitrate dehydrogenase (IDH)‐mutated relapsed/refractory acute myeloid leukaemia and myelodysplastic syndromes

British Journal of Haematology, EarlyView.
Rory M. Shallis, Jennifer VanOudenhove, Namrata Chandhok, Justin Watts, Deepa Jeyakumar, Daniel R. Reed, Jan Phillip Bewersdorf, Diane Durecki, Scott Boerner, Richard F. Little, Steven D. Gore, Jing Li, Xun Bao, Li Chen, Sayak Ghatak, Thomas Prebet, Ranjit S. Bindra, Amer M. Zeidan, Stephanie Halene   +18 more
wiley   +1 more source

Liquid Biopsy and Multi‐Cancer Early Detection Tests for Cancer Screening: A Scoping Review

Clinical Genetics, EarlyView.
There is a large body of evidence on liquid biopsy and multi‐cancer detection tests for cancer screening. Most studies addressed test performance outcomes, while fewer addressed clinical outcomes, implementation, and cost‐effectiveness. No studies evaluated cancer mortality.
Tessa Robinson, Marian Saab, Lily Thao Nguyen, Pooja Kochar, Olivia Meggetto, Jill Tinmouth, Meghan J. Walker   +6 more
wiley   +1 more source

Reproductive Challenges in Mutated BRCA Gene Carriers: A Narrative Review. [PDF]

Curr Issues Mol Biol
Vouza M, Papadoliopoulou M, Dimitrakakis K, Zografos G, Michalopoulos NV, Arkadopoulos N.   +5 more
europepmc   +1 more source

Meme kanserinde BRCA-1 ve BRCA-2’de sık görülen nokta mutasyonların (polimorfizm) bölgemizde görülme sıklığı

, 2016
Giriş ve Amaç: Meme kanseri dünyada kadınlar arasında en sık görülen malign tümör olup, tüm kadın kanserlerinin yaklaşık %25’ini oluşturmaktadır. Her yaş grubunda görülebilmesine karşın genç yaşta ailesel olguların dışında nadir olarak görülmektedir ...
Akkuzu, Mustafa Zanyar
core  

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Subtype-Dependent Transcriptional Coupling Between DNMT1 and E2F-Linked Proliferative Programs in Breast Cancer: A Dual-Cohort Transcriptomic Analysis. [PDF]

J Cancer
Xiao P, Xie Y, Niu R, Shan M, Dong Z, Shi Y.   +5 more
europepmc   +1 more source

Additional sectioning and AI‐assisted diagnosis reveal underdiagnosis of serous (pre)malignancies in fallopian tube specimen from BRCA1/2 carriers

Histopathology, EarlyView.
This paper shows that deeper sections reveal additional STICs and HGSCs in risk‐reducing salpingo‐oophorectomy specimens of patients who did not have a STIC or HGSC diagnosis but did develop peritoneal HGSC 10 years after surgery. This adds to the premise that HGSC originates in the fallopian tube.
Anouk B Bouwmeester, Tamar A Gootzen, Marielle Nobbenhuis, Vilius Rudaitis, Caroline B van den Berg, Heleen J van Beekhuizen, Luthy SM Alcalá, Dineke PM Smedts, Nicole CM Visser, Viola Verhoef, Trudy GN Jonges, Ronald P Zweemer, Alicia Leon‐Catillo, Carlijn Lems, Joanne A de Hullu, Jeroen AWM van der Laak, Miranda P Steenbeek, Michiel Simons   +17 more
wiley   +1 more source

The role of KIAA1467 in breast cancer: insights from pan-cancer and single-cell sequencing analysis. [PDF]

Transl Cancer Res
Miao S, Sun X, Wang X, Ni Q, Mao W, Zhuang Z, Fang J.   +6 more
europepmc   +1 more source