Results 171 to 180 of about 50,723 (266)

DRAM1‐defined autophagy‐JAK‐STAT‐Tregs axis drives immunosuppression and predicts immunotherapy response in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
Tumour‐intrinsic DRAM1, induced by DNA damage and IFN‐γ, activates an autophagy/JAK‐STAT axis that recruits Tregs, causing CD8+ T cell exhaustion and establishing a self‐sustaining, immunotherapy‐resistant “cold” tumour microenvironment. Abstract Background DNA damage‐regulated autophagy modulator 1 (DRAM1) is a lysosomal protein involved in autophagy ...
Jinchun Wu, Hailing Yang, Jingjing Cao, Min Yang, Wanqiao Cao, Yonglei Liu, Yunfeng Cheng, Fanli Hua   +7 more
wiley   +1 more source

Identification and validation of a seven-gene metastasis-associated prognostic model in breast cancer. [PDF]

Front Genet
Yao Y, Zheng Y, Xie J, Liu H, Chen C, Cao J, Yin TT.   +6 more
europepmc   +1 more source

Identification of immune‐infiltrated and stroma‐enriched subtypes in HER2+ breast cancer

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
Integrative profiling identifies five immune–stromal microenvironment subtypes in HER2+ breast cancer. An immune‐infiltrated subtype shows robust immune activation and favourable survival. A stroma‐dominant subtype exhibits ECM remodelling and poorer prognosis.
Ying Yang, Wei Zeng, Xin Wei, Juan Li, Xuelian Chen, Zuyi Zhou, Bo Yang, Jie Li, Li Li   +8 more
wiley   +1 more source

CDC42SE1 as a novel prognostic biomarker with immunomodulatory associations in breast invasive carcinoma. [PDF]

Discov Oncol
Lu Y.
europepmc   +1 more source

Single‐cell profiling reveals peripheral blood immune landscape remodelling in breast cancer lymph node metastasis

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
scRNA‐seq reveals pro‐metastatic neutrophil and exhausted T/NK subsets in BC patients with LN metastasis. Interferon‐stimulated neutrophils secrete LGALS9, drives T/NK cell exhaustion via HAVCR2. Neutralising LGALS9 restores T‐cell anti‐tumour activity, suggesting a novel therapeutic target.
Bo Chen, Kang Ma, Yunjie Wang, Liulu Zhang, Xinyue Feng, Cheng Long, Xuejing Tan, Kun Wang   +7 more
wiley   +1 more source

Cervical cancer with BRCA1 gene mutations: case reports and literature review. [PDF]

Front Oncol
Yang J, Song L, Yin R, Zhong L.
europepmc   +1 more source

Mapping metabolic reprogramming in lung and breast cancer through integrative bioinformatics. [PDF]

PLoS One
Al-Damook N, Sakkal M, Khair M, Mousa WK, Ghemrawi R.   +4 more
europepmc   +1 more source

Integrative Bioinformatics Analysis Reveals COL13A1 and COL23A1 as Potential Diagnostic and Prognostic Biomarkers in Thyroid Cancer

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Thyroid cancer, the most prevalent endocrine malignancy globally, poses challenges owing to the limited understanding of its molecular drivers. Previous research has highlighted collagen genes, such as COL13A1 and COL23A1, as key players in thyroid cancer.
Md. Wahidul Islam, Md. Minhajur Rahman, Homaira Naznin, Md. Shohel Hossain, Tahmina Akter, Zayeda Akter Shatabde, Md. Jubayer Hossain   +6 more
wiley   +1 more source

The effect of PARP inhibitor-based targeted therapy on BRCA-mutated ovarian cancer: systematic literature review. [PDF]

Front Oncol
Panjarwanto DA, Nabila P, Octavia L, Indrawan IWA, Utomo RP, Permana AY, Kaspan, Adnyana IGHE, Javier RM, Akbar MZH.   +9 more
europepmc   +1 more source

Prevalence of BRCA 1 and BRCA 2 in breast cancer in India

The Breast, 2019
openaire   +1 more source