Results 91 to 100 of about 50,723 (266)
Health and Disease After Assisted Reproductive Technology
Fertility & Reproduction, 2019 Long-term health outcomes after ART have largely focused on offspring health and perinatal parameters. Longer-term health outcomes in female patients remain difficult to fully assess.
Cathy Allen
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Exploration, EarlyView.SGO2 interacts with BRCA1 to inhibit BRCA1 ubiquitination and degradation, thereby promoting BRCA1‐induced DNA damage repair signaling and reducing the chemo sensitivity of LUADa. OA targets glycolysis to disrupt H3K18la‐ and H3K27ac‐mediated chromatin accessibility, repressing SGO2 transcription and subsequently alleviating SGO2‐mediated cancer ...
Xian Lin +6 more
wiley +1 more source
Cancer Management and Research, 2022 Takashi Matsumoto, Masaki Shiota, Leandro Blas, Masatoshi Eto Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanCorrespondence: Masaki Shiota, Department of Urology, Graduate School of Medical Sciences, Kyushu ...
Matsumoto T, Shiota M, Blas L, Eto M
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Molecular Genetics & Genomic Medicine, 2020 Background Colorectal cancer (CRC) patients diagnosed with Lynch syndrome (LS) are recommended genetic testing. Increasing numbers of germline variants involved in homologous recombination have been identified in suspected LS patients.
Yun Xu +4 more
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, 2023 BRCA1 and BRCA2 genes encode proteins that have important roles in DNA repair and act as tumor suppressors. Though the sequence and structure of the proteins produced by BRCA1 and BRCA2 are different, they have similar biological activities. Both BRCA gene products are reported to interact with the RAD51 protein, which is essential for DNA repair ...
Divya Bhargavi Pulukuri +5 more
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International Journal of Cancer, EarlyView.Basal‐like breast cancer (BLBC) is aggressive and often exhibits inherent or acquired resistance to radiotherapy (RT), a primary treatment option. RT resistance is underpinned by molecular alterations, many of which are poorly understood. Here, RT‐induced transcriptomic changes were analyzed using bulk and spatial sequencing in a BLBC mouse model and ...
Garyfallia Pantelaiou‐Prokaki +12 more
wiley +1 more source
International Journal of Cancer, EarlyView.The detection of tumor‐infiltrating lymphocytes (TILs) is a positive prognostic factor in ovarian cancer. Moreover, TILs are significantly boosted by immunotherapy, though ovarian cancer patients have seen limited benefit from immune therapies. This study investigated the safety and feasibility of TIL therapy combined with PD‐1 and LAG‐3 inhibitors in ...
Tine J. Monberg +9 more
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Efficacy of PARP Inhibitors in the Treatment of Ovarian Cancer: A Literature-Based Review
Asian Journal of Oncology, 2019 Poly (ADP-ribose) polymerase (PARP) inhibitors are a unique class of therapeutic agents that focus on tumors with deficiencies in the homologous recombination DNA repair mechanism.
Vikas Goswami +7 more
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International Journal of Cancer, EarlyView.Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel +26 more
wiley +1 more source
Journal of Inflammation Research, 2022 Nan Wang,1 Yuanting Gu,1 Lin Li,1 Jiangrui Chi,1 Xinwei Liu,1 Youyi Xiong,1 Chaochao Zhong2 1Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Plastic Surgery, The ...
Wang N +6 more
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