Results 81 to 90 of about 65,986 (255)

BRCA Share: A Collection of Clinical BRCA Gene Variants

, 2016
International audienceAs next-generation sequencing increases access to human genetic variation, the challenge of determining clinical significance of variants becomes ever more acute. Germline variants in the BRCA1 and BRCA2 genes can confer substantial
Rai, Ghadi, Sinilnikova, Olga, Love, Angela, Trautman, Edwin, Révillion, Françoise, Vilquin, Paul, Weymouth, Katelyn S, Beaudoux, Olivia, Nery, Camille R, Salgado, David, Sobol, Hagay, Collod-Beroud, Gwenaelle, Lizard, Sarab, Derive, Nicolas, Buell, Crystal M, Divincenzo, Christina, Muller, Danièle, Vaur, Dominique, Braastad, Corey D, Eisenberg, Marcia, Garrec, Céline, Béroud, Christophe, Bressac-de Paillerets, Brigitte, Sevenet, Nicolas, Letovsky, Stanley I, Elzinga, Christopher D, Toulas, Christine, Coulet, Florence, Karbassi, Izabela, Caputo, Sandrine M, Houdayer, Claude, Nagan, Narasimhan, Strom, Charles M, Stoppa-Lyonnet, Dominique, Willis, Alecia, Bignon, Yves Jean, Bronner, Myriam   +36 more
core   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source

Disentangling Heterogeneous Molecular Networks for Multi‐Omics‐Driven Cancer Driver Discovery

Advanced Science, EarlyView.
DRIVE integrates PPI topology and pan‐cancer multi‐omics profiles through dual‐view graph disentanglement, contrastive representation learning, and joint optimization. Across six PPI networks, DRIVE outperforms ten baselines and remains robust to structural and annotation perturbations.
Xinjing Gong, Ji Li, Mu Su, Peishen Yu, Te Ma, Ruiyang Zhai, Chenye Zhang, Mengyan Zhang, Yan Zhang   +8 more
wiley   +1 more source

Clinicopathological characteristics and BRCA1/BRCA2 pathogenic variants of patients with breast cancer

Polish Journal of Pathology
Although BRCA genes are well-known breast cancer genes, the clinicopathological features of breast cancer patients carrying BRCA1/2 pathogenic variants have not been adequately defined.
Nazan Eras, Ferah Tuncel, Zuhal Altıntas, Sema Erden   +3 more
doaj   +1 more source

A Case-Based Clinical Approach to the Investigation, Management and Screening of Families with BRCA2 Related Prostate Cancer

The Application of Clinical Genetics, 2021
Bradley King,1 Jana McHugh,2 Katie Snape3 1Institute of Medical and Biomedical Education, St. George’s, University of London, London, UK; 2Department of Oncogenomics, Institute of Cancer Research, London, UK; 3Department of Clinical Genetics, St ...
King B, McHugh J, Snape K
doaj  

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

Combination of the PARPi and ARSi in advanced castration resistant prostate cancer: a review of the recent phase III trials

Exploration of Targeted Anti-tumor Therapy
Tumors with an impaired ability to repair DNA double-strand breaks by homologous recombination, including those with alterations in breast cancer 1 and 2 (BRCA1 and BRCA2) genes, are very sensitive to blocking DNA single-strand repair by inhibition of ...
Martina Panebianco, Vittore Cereda, Mario Rosario D’Andrea   +2 more
doaj   +1 more source

Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”

4 open, 2019
It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Clinicopathologic characteristics and BRCA-1/BRCA-2 mutations of Turkish patients with breast cancer

, 2011
Background: BRCA-1 and BRCA-2 are two major susceptibility genes for breast cancer. Between 30-70 %. of hereditary breast cancers are thought to be attributed to mutations in BRCA-1 or BRCA-2. The aim of our study was to investigate the clinicopathologic
Aydin, F., Fidan, E., Ozdemir, F., Kavgaci, H., Akagun, T., Yildiz, Bülent   +5 more
core   +1 more source