Results 71 to 80 of about 50,723 (266)

İnvaziv Duktal Meme Kanserli Genç Olgularda MR Bulgularının, BRCA Mutasyon ve İmmünohistokimyasal Sonuçları ile Korelasyonu.

Sakarya Tıp Dergisi, 2019
Amaçİnvaziv duktal karsinomalı 40 yaş altı hastalarda; prognozla ilişkisi belirlenen ve tedavi seçiminde rol oynayan immünohistokimyasal değerlendirme ve BRCA mutasyonları ile manyetik rezonans görüntülemede IDEAL ve DISCO sekanslarda elde edilen sinyal ...
Kıyasettin Asil, Havva Belma Koçer, Yasemin Anıl Eyüboğlu Tanrıverdi, Mine Urfalı, Furkan Ertürk Urfalı   +4 more
doaj   +1 more source

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

Identification of BRCA1/2 p.Ser1613Gly, p.Pro871Leu, p.Lys1183Arg, p.Glu1038Gly, p.Ser1140Gly, p.Ala2466Val, p.His2440Arg variants in women under 45 years old with breast nodules suspected of having breast cancer in Burkina Faso

Biomolecular Concepts, 2019
Breast cancer is the top cause of cancer mortality among women in the world and the second in Africa. The aims of this study were to: i) identify women with breast nodules suspected of having breast cancer ii) sequence the BRCA1 and BRCA2 genes and iii ...
Sagna Tani, Bonora Elena, Ouedraogo Marie Nabonswindé Lamoussa, Fusco Daniela, Zoure Abdou Azaque, Bisseye Cyrille, Djigma Florencia, Kafando Jacques Gilbert, Zongo Nayi, Douamba Zoenabo, Obiri-Yeboah Dorcas, Turchetti Daniela, Pietra Virginio, Lompo Olga Melanie, Ouedraogo Charlemagne, Seri Marco, Simpore Jacques   +16 more
doaj   +1 more source

Risk factors of ovarian cancer: family history, obesity and oral contraceptive use

Journal of Education, Health and Sport, 2020
Introduction and purpose:  Ovarian cancer (OC) takes the 7th place among most common female malignancies worldwide. There are almost 240 thousand of new cases diagnosed each year and the number is constantly growing.
Aleksandra Amalia Kuchnicka, Martyna Zielińska, Natalia Zarankiewicz, Katarzyna Kosz, Halina Piecewicz-Szczęsna   +4 more
doaj   +1 more source

Chemotherapy‐induced peripheral neuropathy increases nontraumatic fracture risk in breast cancer survivors

JBMR Plus, 2021
Chemotherapy is a common treatment for breast cancer (BrCa) and can cause chemotherapy‐induced peripheral neuropathy (CIPN). CIPN contributes to falls, and is thus a potential risk factor for nontraumatic fractures (NTFx); yet, the effect of CIPN on NTFx
Brendan L. McNeish, James K. Richardson, Sarah G. Bell, Daniel G. Whitney   +3 more
doaj   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

BRCA Testing in Serbia and Montenegro [PDF]

Hereditary Cancer in Clinical Practice, 2006
Serbia and Montenegro is the most recent country to have joined the European integration processes in the Western Balkan region. War has troubled this country for more than ten recent years. Post-war conditions have been as severe as those during the war and include poverty and a lack of new, highly sophisticated technologies and trained professionals ...
openaire   +3 more sources

Rising Pancreatic Cancer Incidence in Young Japanese Women and Increasing Distal Pancreatectomy in Older Adults: A Nationwide Claims‐Based Analysis From 2016 to 2023

Annals of Gastroenterological Surgery, EarlyView.
This nationwide claims‐based study analyzed recent trends in pancreatic cancer incidence (2016–2021) and surgery (2016–2023) in Japan. The study revealed a rising incidence of pancreatic cancer, notably among young women, and an increasing use of distal pancreatectomy among older adults.
Masamitsu Kido, Ryo Morimura, Yusuke Yamamoto, Tomohiro Arita, Shingo Nakashima, Katsutoshi Shoda, Taisuke Imamura, Hidemasa Kubo, Kengo Yoshii, Iichiroh Onishi, Atsushi Shiozaki   +10 more
wiley   +1 more source