Results 11 to 20 of about 65,986 (255)

bio-liucheng/brca-singlecell: October 16, 2022

, 2022
Single-cell BRCA analysis ...
bio-liucheng
core   +1 more source

3D And 2D RNA Structure Prediction Of The BRCA2 Gene And Its Silencing RNA In The Breast Cancer

Walisongo Journal of Chemistry, 2020
Breast cancer is one of the most threatening diseases for women. It is found that BRCA2 gene plays a significant role in breast cancer, provided that mutations occurred.
Ryan Wijaya, Arli Aditya Parikesit, Rizky Nurdiansyah   +2 more
doaj   +1 more source

Bcr/Abl Interferes with the Fanconi Anemia/BRCA Pathway: Implications in the Chromosomal Instability of Chronic Myeloid Leukemia Cells [PDF]

, 2010
Chronic myeloid leukemia (CML) is a malignant clonal disorder of the hematopoietic system caused by the expression of the BCR/ABL fusion oncogene. Although it is well known that CML cells are genetically unstable, the mechanisms accounting for this ...
Valeri, Antonio, Beatriz Albella, Agirre, Xabier, Casado, José A., Pujol, MR, Rio, P, Bueren, Juan, Ariana Jacome, Albella Beatriz, Maria Eugenia Alonso-Ferrero, Juan A Bueren, Alonso-Ferrero, Maria Eugenia, María Roser Pujol, Hanenberg, H. (H.), Jacome Ariana, Alonso-Ferrero, ME, Hanenberg, H, Perez, L, Pérez-Fuentes, L. (Laura), Agirre, X, Jacome, A, Juan A. Bueren, Jacome, Ariana, Río Paula, Pujol María Roser, Surrallés Jordi, Prosper-Cardoso, F. (Felipe), Pérez Laura, Maria José Calasanz, Surralles, J. (Jordi), Hanenberg, Helmut, Prosper Felipe, Helmut Hanenberg, Pérez, Laura, Casado, J. (J.A.), Jacome, A. (Ariana), Albella, Beatriz, Bueren, JA, Hanenberg Helmut, Agirre Xabier, Bueren, J.A. (Juan A.), Valeri, A. (Antonio), Rio, P. (Paula), Calasanz-Abinzano, M.J. (Maria Jose), Prosper, F, José A Casado, Laura Pérez, Paula Río, Río, Paula, Antonio Valeri, Casado José A., Valeri Antonio, Jordi Surrallés, Casado, JA, Calasanz Maria José, Felipe Prosper, Surralles, J, José A. Casado, Calasanz, MJ, Albella, B, Albella, B. (B.), Alonso-Ferrero Maria Eugenia, Valeri, A, Alonso-Ferrero, M. (M.E.), Pujol, M.R. (María Roser), Bueren Juan A., Aguirre-Ena, X. (Xabier), Xabier Agirre, Prosper, Felipe, Calasanz, M.J., Pujol Calvet, Maria Roser, Surralles, Jordi   +71 more
core   +2 more sources

Olaparib in the metastatic HER2-negative breast cancer setting

Медицинский совет, 2020
Understanding of cancer biology is at the cornerstone of design of new and effective treatment strategies. Identification of molecular drivers of tumor growth and progression allow identify right patient for the right treatment for personalized treatment
L. G. Zhukova, E. I. Khatkova, I. P. Ganshina, I. V. Kolyadina, E. V. Lubennikova   +4 more
doaj   +1 more source

Surgical menopause in BRCA-mutated women: metabolic aspects and impact on the quality of life [PDF]

, 2023
openRIASSUNTO Presupposti dello studio La scoperta della mutazione dei geni BRCA 1 e BRCA 2, correlata a soprattutto al cancro della mammella e dell’ovaio, ha reso necessaria l’individuazione di percorsi terapeutici dedicati per le pazienti.
PETRONE, TERESA
core  

Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer

Cancer Biology & Medicine, 2023
Objective: The choice of chemotherapeutic regimen for triple-negative breast cancer (TNBC) remains controversial. Homologous recombination deficiency (HRD) has attracted increasing attention in informing chemotherapy treatment.
Yimeng Chen, Xue Wang, Feng Du, Jian Yue, Yiran Si, Xiaochen Zhao, Lina Cui, Bei Zhang, Ting Bei, Binghe Xu, Peng Yuan   +10 more
doaj   +1 more source

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition

Cell Reports, 2015
Resolution of DNA double-strand breaks (DSBs) is essential for the suppression of genome instability. DSB repair in transcriptionally active genomic regions represents a unique challenge that is associated with ataxia telangiectasia mutated (ATM) kinase ...
Shane M. Harding, Jonathan A. Boiarsky, Roger A. Greenberg   +2 more
doaj   +1 more source

Fertility in BRCA mutation carriers: counseling BRCA-mutated patients on reproductive issues.

, 2020
Objectives Genetic testing rates for hereditary breast and ovarian cancer (HBOC) have steadily increased during the past decades resulting in a growing population of young and healthy mutation carriers. Available data on fertility issues in BRCA mutation
Siegenthaler, Franziska, Imboden, Sara, Knabben, Laura, Mueller, Michael D.   +3 more
core   +1 more source

Acquired Treatment Resistance in a Patient with Metastatic PD-L1-Positive Breast Cancer and Germline BRCA1 Mutation

Case Reports in Oncology, 2023
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with higher rates of relapse and mortality compared to other subtypes. Chemotherapy has been a mainstream treatment approach for TNBC due to the lack of therapeutic
Toko Kumeta, Kei Yamaguchi, Ryosuke Hayami, Kazumori Arai, Michiko Tsuneizumi, Ryoichi Matsunuma   +5 more
doaj   +1 more source

Challenges of Genomic Testing for Hereditary Breast and Ovarian Cancers

The Application of Clinical Genetics, 2021
Lindsey McAlarnen, Kristen Stearns, Denise Uyar Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USACorrespondence: Denise UyarDivision of Gynecologic Oncology, Department of ...
McAlarnen L, Stearns K, Uyar D
doaj