Results 21 to 30 of about 50,723 (266)

REPEATED OPTIMAL CYTOREDUCTIVE SURGERIES IN COMBINED MODALITY TREATMENT OF OVARIAN CANCER. CASE REPORT

Сибирский онкологический журнал, 2017
To date, the algorithm for the treatment of recurrent ovarian cancer and the criteria for selecting patients for performing secondary cytoreductive surgeries have not been fully developed.
S. V. Molchanov, L. A. Kolomiets, O. V. Shpilyeva   +2 more
doaj   +1 more source

Overall survival analysis of > 65-year-old patients with breast cancer based on their molecular, clinicopathological and laboratory factors

Archives of Medical Science, 2022
Introduction The objective of the present study was to characterize > 65-year-old patients with breast cancer according to clinicopathological, molecular and laboratory factors.
Joanna Huszno, Zofia Kolosza, Jolanta Mrochem -Kwarciak, Ewa Grzybowska   +3 more
doaj   +1 more source

A study of somatic BRCA variants and their putative effect on protein properties in malignant mesothelioma

Pleura and Peritoneum, 2023
The aim of this study is to analyze the prevalence of somatic mutations in BRCA1 and BRCA2 in malignant mesothelioma and their putative impact on protein properties.
Krishnamurthy Kritika, Oh Kei Shing, Alghamdi Sarah, Sriganeshan Vathany, Poppiti Robert   +4 more
doaj   +1 more source

3D And 2D RNA Structure Prediction Of The BRCA2 Gene And Its Silencing RNA In The Breast Cancer

Walisongo Journal of Chemistry, 2020
Breast cancer is one of the most threatening diseases for women. It is found that BRCA2 gene plays a significant role in breast cancer, provided that mutations occurred.
Ryan Wijaya, Arli Aditya Parikesit, Rizky Nurdiansyah   +2 more
doaj   +1 more source

Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer

Cancer Biology & Medicine, 2023
Objective: The choice of chemotherapeutic regimen for triple-negative breast cancer (TNBC) remains controversial. Homologous recombination deficiency (HRD) has attracted increasing attention in informing chemotherapy treatment.
Yimeng Chen, Xue Wang, Feng Du, Jian Yue, Yiran Si, Xiaochen Zhao, Lina Cui, Bei Zhang, Ting Bei, Binghe Xu, Peng Yuan   +10 more
doaj   +1 more source

Olaparib in the metastatic HER2-negative breast cancer setting

Медицинский совет, 2020
Understanding of cancer biology is at the cornerstone of design of new and effective treatment strategies. Identification of molecular drivers of tumor growth and progression allow identify right patient for the right treatment for personalized treatment
L. G. Zhukova, E. I. Khatkova, I. P. Ganshina, I. V. Kolyadina, E. V. Lubennikova   +4 more
doaj   +1 more source

ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition

Cell Reports, 2015
Resolution of DNA double-strand breaks (DSBs) is essential for the suppression of genome instability. DSB repair in transcriptionally active genomic regions represents a unique challenge that is associated with ataxia telangiectasia mutated (ATM) kinase ...
Shane M. Harding, Jonathan A. Boiarsky, Roger A. Greenberg   +2 more
doaj   +1 more source

Acquired Treatment Resistance in a Patient with Metastatic PD-L1-Positive Breast Cancer and Germline BRCA1 Mutation

Case Reports in Oncology, 2023
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with higher rates of relapse and mortality compared to other subtypes. Chemotherapy has been a mainstream treatment approach for TNBC due to the lack of therapeutic
Toko Kumeta, Kei Yamaguchi, Ryosuke Hayami, Kazumori Arai, Michiko Tsuneizumi, Ryoichi Matsunuma   +5 more
doaj   +1 more source

Germline landscape of BRCAs by 7-site collaborations as a BRCA consortium in Turkey

The Breast, 2022
BRCA1/2 mutations play a significant role in cancer pathogenesis and predisposition particularly in breast, ovarian and prostate cancers. Thus, germline analysis of BRCA1 and BRCA2 is essential for clinical management strategies aiming at the identification of recurrent and novel mutations that could be used as a first screening approach.
Atil Bisgin, Sebnem Ozemri Sag, Muhammet E. Dogan, Mahmut S. Yildirim, Aydeniz Aydin Gumus, Nejmiye Akkus, Ozgur Balasar, Ceren D. Durmaz, Recep Eroz, Sule Altiner, Adem Alemdar, Lamia Aliyeva, Ibrahim Boga, Fethi S. Cam, Berkcan Dogan, Onur Esbah, Abdullah Hanta, Cem Mujde, Cemre Ornek, Sinem Ozer, Cagla Rencuzogullari, Ozge Sonmezler, Sevcan Tug Bozdogan, Munis Dundar, Sehime G. Temel   +24 more
openaire   +9 more sources

DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function

Cell Reports, 2015
Expression of type I interferons (IFNs) can be induced by DNA-damaging agents, but the mechanisms and significance of this regulation are not completely understood. We found that the transcription factor IRF3, activated in an ATM-IKKα/β-dependent manner,
Qiujing Yu, Yuliya V. Katlinskaya, Christopher J. Carbone, Bin Zhao, Kanstantsin V. Katlinski, Hui Zheng, Manti Guha, Ning Li, Qijun Chen, Ting Yang, Christopher J. Lengner, Roger A. Greenberg, F. Brad Johnson, Serge Y. Fuchs   +13 more
doaj   +1 more source