Results 31 to 40 of about 65,986 (255)
BRCA-EU mutation signature analysis.
, 2019 a SNV mutation signatures. SNVs are organized according to the SNV type (color). Within each type, SNVs are further organized into the pattern of flanking nucleotides (A—A, A—C, …,T—G, T—T). b SV mutation signatures.
Sohrab P. Shah (220828) +6 more
core +1 more source
BRCA and Pancreatic Cancer [PDF]
, 2013 Germline mutations in BRCA genes have been associated with pancreatic cancer. Laboratory and clinical data suggest that patients with BRCA mutations may be more responsive to therapy consisting of conventional chemotherapy with a poly(ADP-ribose ...
Brennan, Gregory T +2 more
core +1 more source
, 2023 We aimed to estimate the incremental lifetime effects, costs, and net-monetary-benefit (NMB) of knowing BRCA information by testing of patients with low-risk localized prostate cancer (PCa) in the US and guiding subsequent screening and treatment, and ...
Joanne Jeter (14518305) +5 more
core +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
A novel multi-analyte serum panel combining CA-125, HE4, microrna-200a, and interleukin-6 for the preclinical detection of high-grade serous ovarian carcinoma in women with pathogenic BRCA1/2 variants [PDF]
Journal of Medical BiochemistryBackground: High-grade serous ovarian cancer (HGSOC), which is common among pathogenic variant carriers of BRCA1 or BRCA2, has high mortality rates due to latestage diagnosis, and therefore, it is important to have effective surveillance methods ...
Xie Jiaqiong +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Инновационная медицина КубаниObjective: To evaluate a correlation of clinically relevant markers between a patient-derived xenograft (PDX) model and triple-negative breast cancer (TNBC).Materials and methods: For the PDX model of TNBC, we used tumor tissue from patient E.
I. S. Lyashenko +8 more
doaj +1 more source
DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function
Cell Reports, 2015 Expression of type I interferons (IFNs) can be induced by DNA-damaging agents, but the mechanisms and significance of this regulation are not completely understood. We found that the transcription factor IRF3, activated in an ATM-IKKα/β-dependent manner,
Qiujing Yu +13 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Prognostic significance of germline BRCA mutations in patients with HER2-positive breast cancer. Epidemiological analysis in primary BRCA screens [PDF]
, 2021 Background: HER2-amplified breast cancers are rare amongst BRCA mutation carriers. No data exist regarding clinico-histological characteristics and prognosis of this subgroup of patients. Materials and Methods: Using a retrospective matched cohort design,
Claudia Omarini +8 more
core +1 more source