Results 31 to 40 of about 50,723 (266)

Challenges of Genomic Testing for Hereditary Breast and Ovarian Cancers

The Application of Clinical Genetics, 2021
Lindsey McAlarnen, Kristen Stearns, Denise Uyar Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USACorrespondence: Denise UyarDivision of Gynecologic Oncology, Department of ...
McAlarnen L, Stearns K, Uyar D
doaj  

BRCA and Pancreatic Cancer

JOP : Journal of the pancreas, 2013
Germline mutations in BRCA genes have been associated with pancreatic cancer. Laboratory and clinical data suggest that patients with BRCA mutations may be more responsive to therapy consisting of conventional chemotherapy with a poly(ADP-ribose) polymerase inhibitor (PARPi).
Gregory T, Brennan, Valerie, Relias, Muhammad Wasif, Saif   +2 more
openaire   +2 more sources

BRCA

, 2021
Breast cancer data from ...
openaire   +2 more sources

Response of Estrogen-Receptor-Positive Metastatic Breast Cancer to Olaparib in Late-Line Therapy

Case Reports in Oncology, 2019
Monotherapy with olaparib provides significant benefits over standard therapy in patients with a germline BRCA mutation and human epidermal growth factor receptor 2 (HER2) negative metastatic breast cancer, who had two or fewer previous chemotherapeutic ...
Toko Kumeta, Ryoichi Matsunuma, Kei Yamaguchi, Ryosuke Hayami, Michiko Tsuneizumi   +4 more
doaj   +1 more source

Comparison of Patient Susceptibility Genes Across Breast Cancer: Implications for Prognosis and Therapeutic Outcomes

Pharmacogenomics and Personalized Medicine, 2020
Shira Peleg Hasson,1 Tehillah Menes,2 Amir Sonnenblick1 1Oncology Department, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 2Department of Surgery, Tel Aviv-Sourasky Medical Center and Sackler ...
Peleg Hasson S, Menes T, Sonnenblick A
doaj  

Excellent Response to Olaparib in a Patient with Metastatic Pancreatic Adenocarcinoma with Germline BRCA1 Mutation after Progression on FOLFIRINOX: Case Report and Literature Review

Case Reports in Oncology, 2020
Metastatic pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis. Until recently, cytotoxic chemotherapy was the only treatment option. Currently, there are subgroups of patients with PDAC either with somatic or germline mutations who are ...
Jefferson Rios Pimenta, Serli Kiyomi Nakao Ueda, Renata D’Alpino Peixoto   +2 more
doaj   +1 more source

BRCA immunohistochemistry for screening of BRCA mutation in epithelial ovarian cancer patients

Gynecologic Oncology Reports, 2020
To evaluate BRCA1/2 immunohistochemistry (IHC) as a screening test for germline BRCA1/2 in epithelial ovarian cancer (EOC), tumor tissue from 105 EOC patients who had germline BRCA mutations, including 9 BRCA1 mutations, 6 BRCA2 mutations and 90 no BRCA mutations, were studied. Paraffin-embedded tissue blocks were stained for BRCA1 and BRCA2.
Tarinee Manchana, Patou Tantbirojn, Natkrita Pohthipornthawat   +2 more
openaire   +3 more sources

Cost-Effectiveness Analysis of Maintenance Olaparib in Patients with Metastatic Pancreatic Cancer and a Germline BRCA1/2 Mutation Based on the POLO Trial

Cancer Management and Research, 2020
Mei Zhan,1– 3 Hanrui Zheng,1– 3 Yu Yang,2,4 Zhiyao He,1 Ting Xu,1,3 Qiu Li2,4 1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2West China Biomedical Big Data Center, Sichuan ...
Zhan M, Zheng H, Yang Y, He Z, Xu T, Li Q   +5 more
doaj  

Practical aspects of treating relapsed BRCA-associated ovarian cancer

Медицинский совет, 2019
Ovarian cancer ranks first in the mortality causes pattern of female reproductive cancers in Russia. Treatment of relapsed ovarian cancer remains a significant challenge to practicing oncologists.
A. A. Rumyantse, A. S. Tyulyandina
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source