Results 81 to 90 of about 49,034 (223)
Molecular Genetics & Genomic Medicine, 2020 Background Colorectal cancer (CRC) patients diagnosed with Lynch syndrome (LS) are recommended genetic testing. Increasing numbers of germline variants involved in homologous recombination have been identified in suspected LS patients.
Yun Xu +4 more
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International Journal of Cancer, EarlyView.What's New? Errors in DNA double‐strand break (DSB) repair can lead to mutations, chromosomal instability, and ultimately cancer. Inhibitor of DNA‐binding 3 (ID3), a transcriptional repressor, is crucial to promoting DSB repair and helping maintain genome stability. Here, the authors investigated ID3 regulation of DNA repair via chromatin accessibility
Giuditta Della Corte +10 more
wiley +1 more source
BRCA Mutations in Pancreas Cancer: Spectrum, Current Management, Challenges and Future Prospects
Cancer Management and Research, 2020 Winston Wong,1 Alexander G Raufi,1,2 Rachael A Safyan,1 Susan E Bates,1,3 Gulam A Manji1,4 1Division of Hematology and Oncology, Columbia University Medical Center and New York Presbyterian Hospital Herbert Irving Pavilion, New York, NY 10032, USA ...
Wong W +4 more
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Cancer Management and Research, 2022 Takashi Matsumoto, Masaki Shiota, Leandro Blas, Masatoshi Eto Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanCorrespondence: Masaki Shiota, Department of Urology, Graduate School of Medical Sciences, Kyushu ...
Matsumoto T, Shiota M, Blas L, Eto M
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[BRCA 1 and BRCA 2 gens in breast cancer].
Lijecnicki vjesnik, 2009 The development of molecular genetics last years brought a better understanding of the mechanisms of breast cancer development. "The hereditary" breast cancer is very much connected with the BRCA 1 and BRCA 2 gene mutations. Recent studies suggest a role for BRCA 1 and BRCA 2 in transcriptional regulation, as it possesses a conserved NH2 terminal ring ...
S, Habibović, Z, Hrgović
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International Journal of Cancer, EarlyView.What's New? Adaptive immune responses are typically limited in pancreatic ductal adenocarcinoma, resulting in minimal efficacy of immune checkpoint inhibitors. Tumor Treating Fields (TTFields) therapy, which uses low‐intensity intermediate‐frequency electric fields to disrupt cancer cell processes, has been approved for certain cancers.
Tal Kan +21 more
wiley +1 more source
iMetaMed, EarlyView.Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen +4 more
wiley +1 more source
Efficacy of PARP Inhibitors in the Treatment of Ovarian Cancer: A Literature-Based Review
Asian Journal of Oncology, 2019 Poly (ADP-ribose) polymerase (PARP) inhibitors are a unique class of therapeutic agents that focus on tumors with deficiencies in the homologous recombination DNA repair mechanism.
Vikas Goswami +7 more
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iNew Medicine, EarlyView.ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid +4 more
wiley +1 more source
Journal of Inflammation Research, 2022 Nan Wang,1 Yuanting Gu,1 Lin Li,1 Jiangrui Chi,1 Xinwei Liu,1 Youyi Xiong,1 Chaochao Zhong2 1Department of Breast Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Plastic Surgery, The ...
Wang N +6 more
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