A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining [PDF]
Open Biology, 2016 Loss of p53, a transcription factor activated by cellular stress, is a frequent event in cancer. The role of p53 in tumour suppression is largely attributed to cell fate decisions.
Sylvie Moureau +4 more
doaj +1 more source
Case Reports in Oncology, 2022 A 24-year-old woman suspected of Lynch syndrome was found to carry a BRCA1 pathogenic variant, based on germline multigene panel testing (MGPT). The patient was diagnosed with endometrial carcinoma and underwent modified radical hysterectomy, bilateral ...
Xiaofei Wang +14 more
doaj +1 more source
Endocrine Regulations, 2023 Objective. Single-walled carbon nanotubes (SWCNTs) are considered to be one of the nanomaterials attractive for biomedical applications, particularly in the health sciences as imaging probes and drug carriers, especially in the field of cancer therapy ...
Minchenko Dmytro O. +8 more
doaj +1 more source
Diagnosis and treatment of ovarian cancer in the light of modern molecular genetic achievements
Сибирский онкологический журнал, 2023 The purpose of the study was to systematize and summarize the literature data on the study of clinical and genetic aspects, molecular pathogenesis, as well as new trends in the diagnosis and treatment of ovarian cancer.Material and Methods.
E. M. Kagirova +2 more
doaj +1 more source
Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development
Molecular & Cellular Oncology, 2020 We recently developed a Brca1 coiled-coil mutant mouse model (Brca1CC). Brca1CC/CC results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia.
J. J. Krais, N. Johnson
doaj +1 more source
RPA, RFWD3 and BRCA2 at stalled forks: a balancing act
Molecular & Cellular Oncology, 2020 We recently identified E3 ligase RFWD3 as a modulator of stalled fork stability in BRCA2-deficient cells. We also show that BRCA1 might function upstream of BRCA2 during fork repair and that blocking fork degradation by depleting MRE11 does not guarantee
Haohui Duan, Shailja Pathania
doaj +1 more source
Limited Independent Follow-Up with Germline Testing of Variants Detected in BRCA1 and BRCA2 by Tumor-Only Sequencing [PDF]
Journal of Immunotherapy and Precision OncologyIntroduction Genomic profiling is performed in patients with advanced or metastatic cancer, in order to direct cancer treatment, often sequencing tumor-only, without a matched germline comparator.
Carol J. Nowlen +18 more
doaj +1 more source
Clinicopathological Characteristics of Patients with BRCA Mutation Breast Cancer in North Sumatera: Case Report [PDF]
Middle East Journal of Cancer, 2023 The most common cancer in women is breast cancer (BC) with an incidence of 24.2%. BC in younger patients will in general be more forceful, prompting more awful results and a requirement for more forceful treatment which may bring about a higher ...
Dedy Hermansyah +3 more
doaj +1 more source
Effect of BRCA1 R1325K mutation on proliferation and apoptosis of gallbladder cancer cells
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To investigate the effects of breast cancer susceptibility gene 1 (BRCA1) R1325K mutation [arginine (R) to lysine (K) mutation at amino acid 1325] on the proliferation and apoptosis of gallbladder cancer cell lines GBC-SD and NOZ.Methods·BRCA1 ...
YANG Jingxiao +7 more
doaj +1 more source
Hereditary breast cancer and ovarian cancer: clinical course and treatment
Опухоли женской репродуктивной системы, 2021 This article analyzes current problems associated with surgical and systemic treatment for hereditary breast and ovarian cancers (including those associated with BRCA1/2 gene mutations).
V. V. Semiglazov +2 more
doaj +1 more source