A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining [PDF]
Open Biology, 2016 Loss of p53, a transcription factor activated by cellular stress, is a frequent event in cancer. The role of p53 in tumour suppression is largely attributed to cell fate decisions.
Sylvie Moureau +4 more
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Case Reports in Oncology, 2022 A 24-year-old woman suspected of Lynch syndrome was found to carry a BRCA1 pathogenic variant, based on germline multigene panel testing (MGPT). The patient was diagnosed with endometrial carcinoma and underwent modified radical hysterectomy, bilateral ...
Xiaofei Wang +14 more
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Co-expression of tumor suppressor p53 (TP53) and cancer testis antigens (CTAs) as the possible indicator of “cancer-free” status [PDF]
World Cancer Research Journal, 2023 Objective: Biomarkers are biological substances that can be measured and objectively evaluated as indicators of concrete processes at different levels.
D. Marjanidze +7 more
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Endocrine Regulations, 2023 Objective. Single-walled carbon nanotubes (SWCNTs) are considered to be one of the nanomaterials attractive for biomedical applications, particularly in the health sciences as imaging probes and drug carriers, especially in the field of cancer therapy ...
Minchenko Dmytro O. +8 more
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Diagnosis and treatment of ovarian cancer in the light of modern molecular genetic achievements
Сибирский онкологический журнал, 2023 The purpose of the study was to systematize and summarize the literature data on the study of clinical and genetic aspects, molecular pathogenesis, as well as new trends in the diagnosis and treatment of ovarian cancer.Material and Methods.
E. M. Kagirova +2 more
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İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, 2021 Amaç: Meme kanseri, kadınlarda en yaygın görülen kanser türü olup, Göğüs Kanseri Duyarlılık gen (BRCA1 ve BRCA2) mutasyonlarının meme ve yumurtalık kanserlerinin önemli bir kısmından sorumlu olduğu bilinmektedir.
İlter Güney, Gözde Girgin Özgümüş
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Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development
Molecular & Cellular Oncology, 2020 We recently developed a Brca1 coiled-coil mutant mouse model (Brca1CC). Brca1CC/CC results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia.
J. J. Krais, N. Johnson
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RPA, RFWD3 and BRCA2 at stalled forks: a balancing act
Molecular & Cellular Oncology, 2020 We recently identified E3 ligase RFWD3 as a modulator of stalled fork stability in BRCA2-deficient cells. We also show that BRCA1 might function upstream of BRCA2 during fork repair and that blocking fork degradation by depleting MRE11 does not guarantee
Haohui Duan, Shailja Pathania
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Limited Independent Follow-Up with Germline Testing of Variants Detected in BRCA1 and BRCA2 by Tumor-Only Sequencing [PDF]
Journal of Immunotherapy and Precision OncologyIntroduction Genomic profiling is performed in patients with advanced or metastatic cancer, in order to direct cancer treatment, often sequencing tumor-only, without a matched germline comparator.
Carol J. Nowlen +18 more
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Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy [PDF]
, 2014 BRCA1, a key factor in homologous recombination repair may also regulate base excision repair (BER). Targeting BRCA1-BER deficient cells by blockade of ATM and DNA-PKcs could be a promising strategy in breast cancer.
Abdel-Fatah, TMA +16 more
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